HORMONAL INFLUENCES ON THE NEUROBIOL OF EXCITABLE CELLS

激素对兴奋细胞神经生物学的影响

• 批准号: 3400069
• 负责人: ANDREW H BASS
• 金额: $ 10.24万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-04-01 至 1990-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3400069
• 关键词: action potentials; androgens; autoradiography; cell parasexuality; central nervous system; electron microscopy; electrophysiology; histochemistry /cytochemistry; hormone binding protein; hormone regulation /control mechanism; immunochemistry; membrane structure; neural information processing; neurochemistry; neuroendocrine system; neurophysiology; radioimmunoassay; saltwater environment; steroid hormone; testosterone

I am studying the influences of gonadal steroid hormones on the anatomical and physiological properties of action potential- generating (i.e. electrically excitable) cells. I am using the electromotor system of mormyrids, a group of weakly electric fish from Africa, as a model system. Mormyrids have an electric organ located in the tail that consists of modified muscle cells called electrocytes that together generate an Electric Organ Discharge (EOD). The characteristic properties of the EOD are determined by the anatomy and physiology of the electrocytes. The activity generated by a single electrocyte determines the appearance of the entire EOD. I have found that gonadal steroid hormones (e.g. testosterone) can induce changes in the EOD that mimic natural sex differences. Steroid-induced changes in the EOD are correlated with changes in the morphology of the electrocyte's excitable membranes and the duration of their action potential waveforms. I want to continue studying the cellular mechanisms underlying hormone- induced changes in the anatomy and physiology of the electric organ. I also want to extend my anatomical studies of steroid- binding cells in the brain of electric fish. The effects of steroid hormones on electrocytes may be fundamental to their action on other classes of electrically excitable cells, namely neurons and muscle fibers. The EOD itself is somewhat unique in that it is both a behavior, important in an electrical guidance system and in social communication, and a discrete neurophysiological event. In this way, we can weave an interface between steroid hormone action at functional (i.e. behavior) and mechanistic or cellular levels.

我正在研究性腺类固醇激素对 动作电位的解剖学和生理学特性- 产生（即电兴奋）细胞。 我正在使用 斑尾鱼的电动机系统，一组弱电 来自非洲的鱼，作为模型系统。 斑鸠鱼有电 位于尾部的由改良肌肉细胞组成的器官 称为电细胞，它们共同产生电器官 放电（EOD）。 EOD 的特性是 由电细胞的解剖学和生理学决定。 单个电细胞产生的活性决定了 整个EOD的外观。 我发现性腺类固醇激素（例如睾酮）可以 引起模拟自然性别差异的 EOD 变化。 类固醇引起的 EOD 变化与变化相关 电解质细胞可兴奋膜的形态和 他们的动作电位波形的持续时间。 我想要 继续研究激素背后的细胞机制 引起电的解剖学和生理学变化 器官。 我还想扩展我对类固醇的解剖学研究 电鱼大脑中的结合细胞。 类固醇激素对电细胞的影响可能是 它们对其他类别的电的作用至关重要 可兴奋细胞，即神经元和肌纤维。 爆炸物本身 有点独特，因为它既是一种行为，又是一种重要的行为 电气引导系统和社交交流，以及 离散的神经生理学事件。 这样我们就可以编织一个 类固醇激素作用与功能之间的界面（即 行为）和机械或细胞水平。