HORMONAL INFLUENCES ON THE NEUROBIOL OF EXCITABLE CELLS

激素对兴奋细胞神经生物学的影响

• 批准号: 3400063
• 负责人: ANDREW H BASS
• 金额: $ 12.42万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-04-01 至 1990-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3400063
• 关键词: action potentials; androgens; autoradiography; cell parasexuality; central nervous system; electron microscopy; electrophysiology; histochemistry /cytochemistry; hormone regulation /control mechanism; immunochemistry; membrane structure; neural information processing; neurochemistry; neuroendocrine system; neurophysiology; radioimmunoassay; saltwater environment; steroid hormone; testosterone

I am studying the influences of gonadal steroid hormones on the anatomical and physiological properties of action potential- generating (i.e. electrically excitable) cells. I am using the electromotor system of mormyrids, a group of weakly electric fish from Africa, as a model system. Mormyrids have an electric organ located in the tail that consists of modified muscle cells called electrocytes that together generate an Electric Organ Discharge (EOD). The characteristic properties of the EOD are determined by the anatomy and physiology of the electrocytes. The activity generated by a single electrocyte determines the appearance of the entire EOD. I have found that gonadal steroid hormones (e.g. testosterone) can induce changes in the EOD that mimic natural sex differences. Steroid-induced changes in the EOD are correlated with changes in the morphology of the electrocyte's excitable membranes and the duration of their action potential waveforms. I want to continue studying the cellular mechanisms underlying hormone- induced changes in the anatomy and physiology of the electric organ. I also want to extend my anatomical studies of steroid- binding cells in the brain of electric fish. The effects of steroid hormones on electrocytes may be fundamental to their action on other classes of electrically excitable cells, namely neurons and muscle fibers. The EOD itself is somewhat unique in that it is both a behavior, important in an electrical guidance system and in social communication, and a discrete neurophysiological event. In this way, we can weave an interface between steroid hormone action at functional (i.e. behavior) and mechanistic or cellular levels.

我正在研究性腺类固醇激素对 作用潜力的解剖学和生理特性 - 产生（即电兴奋）细胞。 我正在使用 摩尔米尔的电动系统，一组弱电力 来自非洲的鱼作为模型系统。 摩美有电 器官位于尾巴，由改良的肌肉细胞组成 称为电细胞，共同产生电源器官 放电（EOD）。 EOD的特性是 由电细胞的解剖学和生理学决定。 单一电细胞产生的活性决定了 整个EOD的外观。 我发现性腺类固醇激素（例如睾丸激素）可以 诱导EOD的变化，以模仿自然性别差异。 类固醇引起的EOD变化与变化相关 在电型兴奋的膜的形态中 其动作电位波形的持续时间。 我想要 继续研究激素 - 诱导电气解剖学和电力的生理变化 器官。 我还想扩展我对类固醇的解剖学研究 电鱼大脑中的结合细胞。 类固醇激素对电细胞的影响可能是 他们对其他类别的电动行动的基础 可激发细胞，即神经元和肌肉纤维。 EOD本身 在某种程度上是一个独特的行为，在一个行为中很重要 电气引导系统和社会交流，以及 离散的神经生理事件。 这样，我们可以编织 类固醇激素作用在功能上的界面（即 行为）和机械或细胞水平。