SPARING & LOSS OF FUNCTION AFTER CEREBRAL CORTEX LESIONS

节约

• 批准号: 3384021
• 负责人: BERTRAM R PAYNE
• 金额: $ 13.25万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-02-01 至 1993-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3384021
• 关键词: animal age group; autoradiography; axon reaction; behavior test; brain mapping; cats; dendrites; developmental neurobiology; embryo /fetus; growth /development; histochemistry /cytochemistry; histology; immature animal; neural degeneration; neuroanatomy; retinal ganglion; stereotaxic techniques; visual cortex; visual pathways

The long-term goal of the proposed research is to understand the mechanisms which underlie the behavioral sparing and loss of functions that follow early damage of the cerebral cortex. In the proposed studies, the morphological changes associated with spared and impaired neural functions in cats, following removal of areas 17 and 18 at different stages of development, will be examined. Experiments will focus on survival and degeneration of neurons in the retina and in area PMLS of the cerebral cortex. For the retina, the spatial distribution of morphologically identified surviving ganglion cells will be determined, and the survival related to the pattern of their axon projections in the brain and to the cat's age at the time the damage is incurred. Corollary data on ganglion cell axon projections in the brain will also be obtained. For area PMLS, counts of surviving neurons will be made in each cortical layer, and related to the age of the cat at the time the lesion is incurred. In order to relate the degenerations to the pattern of axon projections, the origin of the pathway, in PMLS to areas 17 & 18, and termination of the reciprocal pathway, will be assessed at the same developmental stages areas 17 & 18 are removed. Additional studies will examine the organization of modified brain pathways from the thalamus and from cortical areas spared by the lesion to area PMLS. Conventional anterogradely and retrogradely transported axoplasmic tracer substances will be employed to identify neurons and brain pathways, and the distribution of surviving neurons and modified pathways will be related to spared functions. The data obtained form these studies may prove fundamental to understanding the neural and psychological disorders that follow damage of the immature cerebral cortex.

拟议研究的长期目标是了解 行为保证和丧失的机制 遵循大脑皮层损害的功能。 在 拟议的研究，与幸免的形态学变化 猫的神经功能受损，在去除区域后 将检查在不同发展阶段的17和18。 实验将集中于神经元的生存和变性 视网膜和大脑皮层的PML区域。 为了 视网膜，形态学鉴定的空间分布 将确定生存的神经节细胞，并生存 与他们在大脑中的轴突投影的模式有关 在造成伤害时猫的年龄。 推论 关于大脑中神经节细胞轴突投影的数据也将是 获得。 对于区域PML，将订立幸存的神经元计数 在每个皮层中，与猫的年龄有关 病变发生的时间。 为了关联退化 轴突投影的模式，路径的起源 PML到17＆18地区，以及倒数途径的终止， 将在17和18的同一发展阶段进行评估是 删除。 其他研究将研究 从丘脑和皮质区域进行了改进的大脑通路 因病变而幸免于区域PML。 传统的同类 逆转运输的轴质示踪剂将是 用于识别神经元和大脑途径，以及 幸存的神经元和修改途径的分布将是 与豁免功能有关。 这些研究获得的数据 可能证明是理解神经和心理的基础 遵循未成熟脑皮质损害的疾病。