Anti-Biofilm Materials Using Multifunctional MOFs

使用多功能 MOF 的抗生物膜材料

基本信息

批准号：
EP/I028080/1
负责人：
Russell Morris
金额：
$ 19.48万
依托单位：
University of St Andrews
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2011
资助国家：
英国
起止时间：
2011 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FI028080%2F1
关键词：
Anti Biofilm Materials Using Multifunctional

项目摘要

Biofilm infections are a major source of nosocomial (hospital-acquired) infections, accounting for ~65% of all those treated in the Western world (according to an estimate in 1999 ). Almost a defining feature of biofilms is their increased resistance to both antimicrobial drugs and to the host animal's own defences. This makes them particularly difficult targets, and even strains of microbe that are effectively treated when in their non-biofilm (planktonic) form are often untreatable when formed in biofilms. There is therefore a great incentive to develop new methods of combating such infections. In this project we will look to develop the commercial and technical aspects of a technology that we originally developed during an EPSRC-funded research projects (GR/T09705/01 Designing Porous Metal-Organic Frameworks to Store and Deliver Large Amounts of Nitric Oxide). We have proven that nitric oxide delivered from metal organic frameworks, a type of highly porous inorganic organic hybrid material, is extremely potent at killing bacteria, even when the bacteria have formed biofilm communities. We have also shown that, because of the very highly porous nature of the metal organic frameworks, we can load drugs or other small molecules simultaneously with the NO. In this project we aim to develop the commercial potential of these materials with a goal of developing a product for the anti-biofilm market. In particular our previous results have shown that we can formulate these materials into polymers suitable for coating medical devices. Over the course of this project we will coat commercial devices with MOF-containing polymers and prove their anti-biofilm activity under industry standard conditions. We will also develop a commercialisation for this technology in the anti-biofilm area as well as improving the strength of our intellectual property and identifying important potential commercial partners.

生物膜感染是医院（医院获得）感染的主要来源，占西方世界中所有治疗患者的65％（根据1999年的估计）。生物膜的几乎一个定义特征是它们对抗菌药物的抵抗力增加了，对宿主动物自身的防御能力。这使得它们变得特别困难，甚至在生物膜中形成时通常无法治疗时，这些靶标的是有效治疗的微生物菌株。因此，有一个很大的动力来开发对这种感染的新方法。在该项目中，我们将寻求开发我们最初在EPSRC资助的研究项目中开发的技术的商业和技术方面（GR/T09705/01设计多孔金属有机框架以存储并提供大量一氧化氮）。我们已经证明，从金属有机框架（一种高度多孔的无机有机杂化材料）中传递的一氧化氮，即使细菌形成生物膜群落也非常有效地杀死细菌。我们还表明，由于金属有机框架的高度多孔性质，我们可以与NO同时加载药物或其他小分子。在这个项目中，我们旨在开发这些材料的商业潜力，目的是为抗生物膜市场开发产品。特别是我们以前的结果表明，我们可以将这些材料制成适合涂层医疗设备的聚合物。在该项目的整个过程中，我们将用含MOF的聚合物覆盖商业设备，并在行业标准条件下证明其抗生物胶片活性。我们还将在抗生物膜地区开发该技术的商业化，并提高我们的知识产权的实力并确定重要的潜在商业伙伴。