Manufacturing the future: Manufacture of Shaped MOF-Polymer Products for Healthcare Applications

制造未来：制造用于医疗保健应用的成型 MOF 聚合物产品

• 批准号: EP/V008498/1
• 负责人: Russell Morris
• 金额: $ 123.22万
• 依托单位: University of St Andrews
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FV008498%2F1
• 关键词: Manufacturing; future; Manufacture; Shaped; MOF

This project will investigate and develop routes to the manufacture and post-processing of extruded polymer-based articles containing porous materials called metal organic frameworks (MOFs). The project will have widespread applicability to the development of many high value and transformative products. Focus will be placed on the manufacture of components for multifunctional medical devices (particularly catheters) that will enable enhanced well-being. The project seeks to establish the pertinent fundamental contributing factors and how these can be controlled, arriving at a set of guidelines for effective manufacture. It will also develop, design and build a prototype process that achieves, for the first time, necessary post-manufacture processing at scale. These dual components will permit the remarkable properties of MOFs to be harnessed to alleviate some of the most pressing challenges of modern society - healthcare associated infections, antimicrobial resistance and heart disease. As such, this project fits within the 21st Century Products Research Vision category. MOFs are one of the most significant classes of materials to be developed in recent times. They are nanoporous solids formed by connecting metal ions or clusters with organic linking molecules to form extended networks. Their huge porosity and accessible surface area (up to 5-6,000m2g-1) makes them absolutely ideal for storage and delivery uses. As a result, there is significant academic activity developing and studying these materials for a diverse range of applications such as gas handling (including carbon capture, hydrogen and methane storage, gas separation, toxic gas capture), environmental remediation and pollution prevention, catalysis, energy applications and drug delivery.To realise the full innovative potential of applying MOFs to polymer-based products, suitable methods for their incorporation and processing must be developed. Many polymer-based articles, including catheter tubing, are manufactured by extrusion. To date, however, there is a lack of studies reported in the literature regarding MOF processing into shaped polymer-based product components using this technique. In addition, there are no studies into the large scale post-processing of such extruded articles to enable MOF activation and subsequent gas loading, which are essential steps for any application requiring gas adsorption/release. This project will address this lack of information on the manufacturing of MOF-based polymer articles and will develop the utilisation of MOFs as delivery agents for the medically useful gas nitric oxide (NO) as a model application.NO is a biological signalling molecule that has antimicrobial, vasodilatory, antithrombotic and wound healing properties. Exogenous delivery of NO has the potential to offer advanced therapies that mimic natural processes and address pressing societal challenges. Currently, only systemic NO delivery is possible using pro-drugs (e.g. glyceryl trinitrate) or, direct inhalation of the gas. However, these approaches can lead to unwanted side-effects. Localised and controlled delivery of NO (e.g. from implantable devices) has long been sought by clinicians but is yet to be realised. NO-releasing MOFs (developed by the applicants) have the potential to achieve this goal if they can be processed successfully into the appropriate devices. Successful incorporation into, for example, urinary, cardiovascular and haemodialysis catheters will reduce healthcare associated infections, alleviate procedural complication during the treatment of heart disease, and reduce the risk of thrombosis during haemodialysis. As is currently the case in many areas of MOF application research, realisation of the potential benefits offered by MOFs is reliant on the successful development and understanding of their processing into end-product form.

该项目将调查并开发途径，以制造和后处理，这些物品的基于挤出的聚合物物品，其中包含称为金属有机框架（MOF）的多孔材料。该项目将广泛适用于许多高价值和变革产品的开发。将重点放在用于多功能医疗设备（尤其是导管）组件的制造上，这些设备将使福祉增强。该项目旨在建立相关的基本贡献因素以及如何控制这些因素，并制定一系列有效制造准则。它还将开发，设计和构建一个原型过程，该过程首次达到必要的后制造后处理。这些双重组成部分将允许MOF的显着特性来减轻现代社会的一些最紧迫的挑战 - 医疗保健相关的感染，抗菌素抵抗和心脏病。因此，该项目符合21世纪的产品研究愿景类别。 MOF是最近要开发的最重要的材料类别之一。它们是通过将金属离子或簇与有机链接分子连接到形成扩展网络的纳米固体。它们巨大的孔隙率和可访问的表面积（高达5-6,000m2g-1）使它们绝对是存储和交付用途的理想选择。结果，为多种应用（包括碳捕集，氢和甲烷存储，气体分离，有毒气体捕获），环境补救和预防预防，能源应用，能源应用和药物交付，必须实现Mof的全部创新潜力，并将其用于PORYMER基于方法，并将其用于量，并将其用于PORYMER基于方法。许多基于聚合物的物品，包括导管管，都是通过挤出制造的。但是，迄今为止，缺乏有关使用此技术将MOF加工为基于聚合物的产品组件的MOF处理的研究。此外，没有研究此类挤出物品的大规模后处理以实现MOF激活和随后的气体负荷，这对于任何需要使用气体吸附/释放的应用来说都是必不可少的步骤。该项目将解决有关基于MOF的聚合物物品制造的信息，并将发展MOF作为医学上有用的气含量氧化物（NO）作为模型应用。 NO的外在交付有可能提供模仿自然过程并应对紧迫社会挑战的先进疗法。当前，只有使用促毒物（例如糖酸酯）或直接吸入气体的系统性输送。但是，这些方法可能导致不必要的副作用。长期以来一直在寻求NO的本地化和受控的NO（例如，从可植入设备中），但尚未实现。如果可以成功地将其处理到适当的设备中，则不释放MOF（由申请人开发）有可能实现此目标。成功地纳入例如尿，心血管和血液透析导管将减少与医疗保健相关的感染，减轻心脏病治疗期间的程序并发症，并降低血液溶解过程中血栓形成的风险。与目前在MOF应用研究的许多领域一样，MOF提供的潜在收益的实现依赖于成功开发和理解其加工成最终产品形式。