Effect of piezoelectric charges on oral microbiome modulation
压电电荷对口腔微生物组调节的影响
基本信息
- 批准号:10189941
- 负责人:
- 金额:$ 24.98万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-04 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAmmoniumAnti-Bacterial AgentsAreaBacteriaBariumBiocompatible MaterialsBiomassChargeChemicalsClinicalClinical ServicesComposite Dental ResinComposite ResinsDentalDental MaterialsDental Restoration FailureDental cariesDentinDevelopmentEconomic BurdenEndodonticsEnsureEnvironmentExcisionExperimental DesignsFailureFillerFormulationFutureGeneral PopulationGenerationsGoalsGrantGrowthHealthHealthcareIn VitroIncidenceIonsLifeMasticationMeasuresMetabolicMicrobial BiofilmsMicroscopyModelingOralOutcomePathogenicityPatientsPatternPeriodicityPlant ResinsPropertyProtocols documentationPublic HealthQuality of lifeRecurrenceResearchRibosomal RNASalivarySamplingSavingsSecondary PreventionSequence AnalysisServicesSilverStreptococcus mutansSurfaceTechnologyTimeTissuesTooth DiseasesTooth LossTooth structureTranslatingUnderserved PopulationWaterWorkZinc Oxideagedbiomaterial developmentclinical practicecomposite restorationcostdental resindysbiosisimprovedin vivoinnovationmechanical propertiesmetatranscriptomemicrobialmicrobiomemicrobiome compositionmicrobiome researchmicroorganismmodels and simulationnanonanoparticleoral biofilmoral microbiomepathogenphysical propertypolymerization shrinkagepolymicrobial biofilmprematurepreventresponserestorationrestorative dentistryrestorative materialsealsuccesstranscriptome sequencing
项目摘要
PROJECT SUMMARY
Secondary caries is considered the leading cause of dental restorations failure. The economic burden of
treating this dental condition is significant at a cost of over $5 billion each year in USA. Improving the seal of
dental materials bonded to dental hard tissues is critical for the prevention of secondary caries, progression
of dental disease and tooth loss. Removing bacteria at the bonded interface will prevent the (bio)chemical
degradation of the bonded materials, and thus, increase the clinical service of restorations. A common
limitation of current antibacterial technologies includes the short durability of the effects due to leaching and
depletion of ions. Therefore, there is an immense need to develop a new generation of dental antibacterial
materials to reduce and eliminate dental diseases at bonded interfaces (e.g. secondary caries). We recently
developed a new composite with piezoelectric properties for antibacterial therapies by incorporating charged
nano-fillers into dental resins. Our innovative approach significantly improves current technologies by using
a single filler with long-lasting antibacterial effects. In this study, we propose to find the optimal amount of
piezoelectric nano-filler to enable the antibacterial effect while retaining high mechanical and physical
properties of the composite (aim 1). In addition, we will evaluate the oral microbiome-modulating effects of
piezoelectric charges to understand the specific changes on the biofilm composition and identify the targeted
species by piezoelectric charges (aim 2). We expect the development of the proposed technology to
significantly impact the dental field by reducing the failure rate of composite restorations, in turn, reducing the
costs associated with those failures, improving the health of patients, and preventing unnecessary loss of
additional tooth structure.
项目概要
继发龋被认为是牙齿修复失败的主要原因。经济负担
在美国,治疗这种牙齿疾病每年花费超过 50 亿美元。改善密封性
与牙齿硬组织粘合的牙科材料对于预防继发性龋齿、进展至关重要
牙齿疾病和牙齿脱落。去除粘合界面处的细菌将防止(生物)化学反应
粘合材料的降解,从而提高修复体的临床服务。一个常见的
当前抗菌技术的局限性包括由于浸出和影响而导致的效果持续时间短。
离子耗尽。因此,迫切需要开发新一代牙科抗菌剂
减少和消除粘合界面处的牙科疾病(例如继发龋)的材料。我们最近
通过结合电荷,开发了一种具有压电特性的新型复合材料,用于抗菌治疗
纳米填料进入牙科树脂。我们的创新方法通过使用显着改进了当前技术
具有持久抗菌效果的单一填充剂。在这项研究中,我们建议找到最佳的用量
压电纳米填料可实现抗菌效果,同时保持高机械和物理性能
复合材料的性能(目标 1)。此外,我们将评估口腔微生物组的调节作用
压电电荷了解生物膜成分的具体变化并识别目标
压电电荷种类(目标 2)。我们预计所提出的技术的发展
通过降低复合修复体的失败率,从而减少对牙科领域的影响
与这些失败相关的成本,改善患者的健康,并防止不必要的损失
额外的牙齿结构。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Santiago Orrego', 18)}}的其他基金
Effect of piezoelectric charges on oral microbiome modulation
压电电荷对口腔微生物组调节的影响
- 批准号:
10461760 - 财政年份:2021
- 资助金额:
$ 24.98万 - 项目类别:
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