INTRANEURAL MICRO-STIMULATION FOR PROSTHETIC SENSATION

神经内微刺激假肢感觉

• 批准号: 3331552
• 负责人: RONALD Raymond RISO
• 金额: $ 27.58万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1995-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3331552
• 关键词: afferent nerve; amputation; arm; biomaterial compatibility; electronic stimulator; evoked potentials; human subject; laboratory rabbit; microelectrodes; nervous system prosthesis; neural plasticity; psychophysics; sensory feedback

The proposed research seeks to develop means to provide amputee patients with enhanced tactile sensation from their prostheses. This effort builds on previous work by using a chronic implanted multichannel microelectrode array to selectively activate individual sensory afferents in order to evoke more natural tactile percepts than has previously been demonstrated using more gross cuff or other electrode interfaces. The research comprises three main activities: 1) An existing multielectrode insertable device will be modified for stimulation of peripheral nerve axons and tested in animals to verify the design and implantation procedure. The animal studies will include analysis of somatosensory evoked potentials; responses to a conditioned behavioral paradigm; and histocompatibility. Stimulus selectivity, threshold stability, and neural damage over time will be evaluated from the animal. studies. 2) Following the initial animal work, we will implant electrode arrays in upper extremity amputee subjects for chronic evaluation. With these subjects we will optimize the stimulation patterns and parameters to maximize the naturalness of the evoked percepts. Differential qualities of contact, light touch, slippage, sustained force and graded skin force will be sought. other information that will be obtained from these studies will be the location, size and stability of the evoked "phantom" sensations and insight regarding the plasticity of the individual's sensory system before and following chronic electrical stimulation of the amputated nerves. 3) The outcome of this project will be a demonstration of the feasibility and desirability of performing microstimulation for sensory replacement in prostheses and design specifications for the implementation of permanent and effective microstimulation systems.

拟议的研究旨在开发截肢者患者的手段 从假体引起的触觉增强。 这项努力 通过使用慢性植入多通道以先前的工作为基础 微电极阵列有选择地激活单个感觉传统 为了唤起比以前更多的自然触觉感知 使用更多的袖口或其他电极界面证明。 这 研究包括三个主要活动： 1）将修改现有的多电极插入设备 刺激周围神经轴突并在动物中进行测试以验证 设计和植入程序。 动物研究将包括 体感诱发潜力的分析；对条件的回应 行为范式；和组织相容性。 刺激选择性， 阈值稳定性和随着时间的流逝神经损害将从 动物。研究。 2）最初的动物工作后，我们将植入电极阵列 用于长期评估的上肢截肢受试者。 与这些 主题我们将优化刺激模式和参数 最大化诱发感知的自然性。 差异品质 接触，轻触，滑板，持续力和渐变皮肤力 将被寻求。将从这些信息获得的其他信息 研究将是唤起的“幻影”的位置，大小和稳定性 关于个人的可塑性的感觉和见解 感觉系统在慢性电刺激之前和之后 截肢神经。 3）该项目的结果将证明可行性 进行微刺激进行感觉替代的可取性 在实施的假体和设计规范中 永久有效的微刺激系统。