INTRANEURAL MICRO-STIMULATION FOR PROSTHETIC SENSATION

神经内微刺激假肢感觉

• 批准号: 3331551
• 负责人: RONALD Raymond RISO
• 金额: $ 29.75万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1995-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3331551
• 关键词: afferent nerve; amputation; arm; electronic stimulator; evoked potentials; human subject; laboratory rabbit; microelectrodes; nervous system prosthesis; neural plasticity; psychophysics; sensory feedback

The proposed research seeks to develop means to provide amputee patients with enhanced tactile sensation from their prostheses. This effort builds on previous work by using a chronic implanted multichannel microelectrode array to selectively activate individual sensory afferents in order to evoke more natural tactile percepts than has previously been demonstrated using more gross cuff or other electrode interfaces. The research comprises three main activities: 1) An existing multielectrode insertable device will be modified for stimulation of peripheral nerve axons and tested in animals to verify the design and implantation procedure. The animal studies will include analysis of somatosensory evoked potentials; responses to a conditioned behavioral paradigm; and histocompatibility. Stimulus selectivity, threshold stability, and neural damage over time will be evaluated from the animal. studies. 2) Following the initial animal work, we will implant electrode arrays in upper extremity amputee subjects for chronic evaluation. With these subjects we will optimize the stimulation patterns and parameters to maximize the naturalness of the evoked percepts. Differential qualities of contact, light touch, slippage, sustained force and graded skin force will be sought. other information that will be obtained from these studies will be the location, size and stability of the evoked "phantom" sensations and insight regarding the plasticity of the individual's sensory system before and following chronic electrical stimulation of the amputated nerves. 3) The outcome of this project will be a demonstration of the feasibility and desirability of performing microstimulation for sensory replacement in prostheses and design specifications for the implementation of permanent and effective microstimulation systems.

拟议的研究旨在开发为截肢患者提供服务的方法 假肢的触觉增强。 这个努力 通过使用长期植入的多通道建立在之前的工作基础上 微电极阵列选择性激活个体感觉传入 为了唤起比以前更自然的触觉感知 使用更粗的袖带或其他电极接口进行了演示。 这 研究包括三项主要活动： 1) 现有的多电极可插入装置将被修改为 刺激周围神经轴突并在动物身上进行测试以验证 设计和植入程序。 动物研究将包括 体感诱发电位分析；对条件反射的反应 行为范式；和组织相容性。 刺激选择性， 阈值稳定性和随时间的神经损伤将通过以下方式进行评估 动物。研究。 2）在最初的动物工作之后，我们将在体内植入电极阵列 上肢截肢受试者进行慢性评估。 有了这些 我们将优化刺激模式和参数以 最大限度地提高诱发感知的自然性。 差异化品质 接触、轻触、滑动、持续力和分级皮肤力 将被寻求。将从中获得的其他信息 研究将是诱发“幻象”的位置、大小和稳定性 关于个体可塑性的感觉和洞察力 慢性电刺激前后的感觉系统 被截肢的神经。 3）该项目的成果将证明可行性 以及进行感觉替代微刺激的必要性 假肢和设计规范的实施 永久有效的微刺激系统。