Bioactive terpenoids as high performance ingredients for industry

生物活性萜类化合物作为高性能工业成分

• 批准号: BB/Y003217/1
• 负责人: Ian Graham
• 金额: $ 88.75万
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FY003217%2F1
• 关键词: Bioactive; terpenoids; performance; ingredients; industry

For the UK to achieve its Net Zero targets there is an urgent need across industrial sectors to replace the reliance on petrochemical based feedstocks with sustainable bio-based feedstock. Croda is a UK based multinational company and global leader in high performance ingredients and technologies that are found in some of the most successful brands in the world across a wide range of markets including Personal, Health and Crop Care. Croda has recently undertaken an Executive Committee level product portfolio review and identified a need to focus innovation activities upon industrial biotechnology as a route to sustainable and biobased ingredients across a broad range of areas. Terpenoids represent one of the largest and most diverse classes of natural products in the world, providing an array of functionalities for different industry sectors ranging from flavour and fragrance to human health and personal care. The Graham laboratory at the University of York is world leading in the discovery and development of different classes of terpenoids from plants and have recently been collaborating with Croda to explore the potential of using these to replace petrochemical derived products in the company's portfolio of ingredients being supplied across a range of industrial sectors. Based on proof of concept work, it is clear there is huge potential. The challenge is that many of these terpene based natural products are not available at commercial scale as they are currently only available in relatively small amounts from the plants that produce them. This project will address this challenge by establishing the biosynthetic route to selected terpenoids that perform in Croda's proprietary platforms and by using a combination of synthetic/engineering biology and industrial biotechnology develop new production platforms that will allow commercial scale-up and development of new biobased products. Croda already have expertise in fermentation based scale-up in so called heterologous host platforms that will complement the gene discovery and laboratory scale engineering of host platforms that will be performed at the University of York. Early leads have already been identified for the Crop Care sector which could have a major impact on the sustainability of agriculture.

为了使英国实现其净零目标，工业部门迫切需要用基于可持续的生物的原料来代替对基于石化的原料的依赖。 Croda是一家位于英国的跨国公司，是高性能成分和技术的全球领导者，在世界上一些最成功的品牌中发现了各种市场，包括个人，健康和作物护理。 Croda最近进行了执行委员会级别的产品组合审查，并确定需要将创新活动集中在工业生物技术上，以此作为在广泛领域的可持续和生物基本成分的途径。 Terpenoids代表了世界上最大，最多样化的天然产品之一，为不同行业的各个领域提供了一系列功能，从风味和香气到人类健康和个人护理。约克大学的Graham实验室在发现和开发植物的不同类别的萜类化合物方面是领先的，最近一直与Croda合作，以探索使用这些植物的潜力，以取代该公司在跨工业领域提供的成分组合中的石化产品组合。根据概念工作的证明，很明显，潜力很大。面临的挑战是，这些基于萜烯的天然产品中的许多人目前仅在生产它们的植物中提供的相对较少的植物可用。该项目将通过建立在Croda的专有平台中执行的萜类化合物的生物合成路线，并结合合成/工程生物学和工业生物技术开发新生产平台，从而允许新生物生产产品的商业规模扩展和开发。 Croda在所谓的异源主机平台中已经具有基于发酵的规模的专业知识，这些平台将补充将在约克大学进行的宿主平台的基因发现和实验室规模工程。早期的领导者已经被确定为农作业护理部门，这可能会对农业的可持续性产生重大影响。