High Value Chemicals from Plants Network

来自植物网络的高价值化学品

• 批准号: BB/L013665/1
• 负责人: Ian Graham
• 金额: $ 185.87万
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FL013665%2F1
• 关键词: Value; Chemicals; Plants; Network

The High Value Chemicals from Plants Network aims to facilitate delivery of one of the four key objectives identified in the 2010 Department of Business Innovation and Skills report on 'Horizon Scanning and Road Mapping for Industrial Biotechnology through to 2025', which is to make the UK a leading producer of high value chemicals in plants. The scale of the economic opportunity associated with the extraction of high value chemicals from plants was summarised in the DBIS report. Plant-derived drugs represent 5.5% of the total pharmaceutical industry with sales revenue of £18 billion, oils and fats derived from oil-crops have a global market size of £500 million - £1 billion and functional foods and nutraceuticals have a global market of £45 billion. Other important applications and market sectors ranging from personal care to flavour and fragrance also rely increasingly on chemicals from plants as there is a growing demand for green, environmentally friendly and sustainable feedstocks across industrial sectors reducing our dependence on products derived from chemical refineries.The Network will provide the leadership to address key technology challenges currently limiting the development of high value chemical based products from plants; covering the entire discovery, development and delivery chain. An Advisory Team drawn from academia and industry will oversee the Network, which already has significant numbers of interested participants covering a wide spectrum of different academic disciplines and industrial interests.The Network will be open to all, to promote the development of a coordinated critical mass of multi-disciplinary expertise; and will facilitate interactions between research providers and users to ensure that research is appropriately targeted to achieving the full potential of industrial biotechnology in the context of high value chemicals from plants. Activities will be directed at identifying novel products and optimising and developing both feedstocks and processes in planta. Additional bio- and chemical-transformation of plant-derived chemicals and the development of alternate microbial- or microalgal based production systems will also be employed where these prove more economical, robust and sustainable.Network activities will include: workshops, industry-hosted open innovation workshops, an annual meeting, training opportunities, Network directory and web-based interactions/ communications. To maximize Network opportunities, we will be proactive in engaging with other networking organizations and international initiatives.The availability of Network proof of concept funds will support timely exploration of challenges and goals identified at Network events. These funds will be uniquely targeted at accessing and developing key technology areas using UK centres of excellence. This strategy will enable the Network to encourage novel technology-based solutions to major industry problems as well as supporting such centres, promoting their use, securing inward investment and further developing the technologies and processes they offer through engagement with the Network. Priority for funds will therefore be for process-led activities and those that have clear potential for further funding or have a route to commercial translation. In addition, the Network will focus on developing challenges ready for future IB funding rounds, such as the 2014 Catalyst fund and Europe's research and innovation programme, Horizon 2020.The Network will operate to a five-year plan with sufficient flexibility to maximize the benefits of scientific and technology advances in response to industrial requirements. All activities are designed to contribute to the overall target, which is to become an active community focused on innovative translatable research, achieving high levels of grant funding and inward investment in high value chemicals from plants, so that the positive impact of IB on the UK's economy is realised.

植物网络的高价值化学品旨在促进2010年商业创新和技能部中确定的四个关键物体之一，有关“地平线扫描和工业生物技术的道路映射至2025年”，这是为了使英国成为工厂中高价值化学品的领先生产商。 DBI报告总结了与从工厂中提取高价值化学物质有关的经济机会的规模。植物衍生的药物占制药业总数的5.5％，销售收入为180亿英镑，源自油料的石油和脂肪的全球市场规模为5亿英镑 - 10亿英镑，功能性食品和营养食品的全球市场为450亿英镑。从个人护理到风味和香气，其他重要的应用和市场领域也越来越依赖于植物的化学物质，因为对工业领域的绿色，环保和可持续的原料的需求不断增长，从而降低了我们对从化学炼油厂产生的产品的依赖。该网络将为当前限制高价值化学物质产品的主要技术挑战，以应对高价值的技术挑战，从而限制了高价值化学物质产品的开发。涵盖整个发现，开发和交付链。一个从学术界和行业中汲取的咨询团队将监督该网络，该网络已经有很多兴趣参与者涵盖各种不同的学科和工业利益的参与者。该网络将向所有人开放，以促进协调的多学科专业知识的协调批判质量；并将促进研究提供者和用户之间的相互作用，以确保在植物高价值化学物质的背景下，适当针对研究以实现工业生物技术的全部潜力。活动将致力于识别新型产品，并优化和开发Planta中的原料和过程。还将采用其他生物和化学化学物质的化学化学物质和基于微藻或微藻的生产系统的开发，这些系统也将被证明是更经济，健壮和可持续的。网络活动包括：研讨会，行业待办事项，行业开放创新研讨会，年度培训机会，培训机会，网络目录和网络互动和互动/通信/通信。为了最大程度地利用网络机会，我们将积极参与其他网络组织和国际计划。网络概念资金的可用性将支持及时探索网络活动中确定的挑战和目标。这些资金将成为使用英国卓越中心访问和开发关键技术领域的独特目标。该策略将使网络能够鼓励针对重大行业问题的新型解决方案以及支持此类中心，促进其使用，确保内向投资并进一步开发通过与网络参与而提供的技术和流程。因此，资金的优先级将用于流程主导的活动，以及那些有明显潜力进行进一步资金或有商业翻译途径的活动。此外，该网络将着重于为未来的IB资助回合制定挑战，例如2014年催化剂基金和欧洲的研究与创新计划Horizo​​n 2020。该网络将对五年计划进行，具有足够的灵活性，以最大程度地提高科学和技术进步对工业需求的福利。所有活动旨在为整体目标做出贡献，该目标将成为一个积极的社区，专注于创新的可翻译研究，从而获得了高水平的赠款资金和对工厂高价值化学物质的内在投资，从而实现了IB对英国经济的积极影响。

项目成果

Mobius Assembly: A versatile Golden-Gate framework towards universal DNA assembly.

• DOI: 10.1371/journal.pone.0189892
• 发表时间: 2018
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Andreou AI;Nakayama N
• 通讯作者: Nakayama N

Miyabeacin: A new cyclodimer presents a potential role for willow in cancer therapy

• DOI: 10.1038/s41598-020-63349-1
• 发表时间: 2020-04
• 期刊: Scientific Reports
• 影响因子: 4.6
• 作者: J. Ward;Yanqi Wu;Claudia Harflett;Hannah Onafuye;D. Corol;Charlotte Lomax;W. Macalpine;J. Cinatl;Mark N. Wass;M. Michaelis;M. H. Beale