Mitochondria, maternal inheritance and the evolution of male life-histories

线粒体、母系遗传和男性生活史的进化

• 批准号: DP170100165
• 负责人: Prof Damian Dowling
• 金额: $ 26.34万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-06-30 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170100165
• 关键词: Mitochondria; maternal; inheritance; evolution; male

This project aims to unravel the extent to which maternal inheritance of the mitochondrial DNA renders it susceptible to accumulating mutations that are harmful only to males; an evolutionary theory called ‘Mother’s Curse’. Left unchecked, Mother’s Curse could threaten the long-term viability of populations. This project will combine experimental techniques in ecology, fruit fly genetics and a platform for measuring physiological phenotypes to test three hypotheses central to the theory. By testing these hypotheses, the project intends to understand the causes of sex differences in physiology, longevity and reproductive health, and improve awareness of evolutionary concepts that may ultimately affect human health.

该项目旨在揭示线粒体DNA的母体遗传的程度，使其容易积累仅有害男性的突变；一个被称为“母亲的诅咒”的进化论。不受限制地，母亲的诅咒可能威胁到人口的长期生存能力。该项目将结合生态学，果蝇遗传学和测量物理表型的平台，以测试该理论中心的三个假设。通过检验这些假设，该项目打算了解生理学，寿命和生殖健康的性别差异的原因，并提高对可能影响人类健康的进化概念的认识。