CORTICAL PROCESSING OF VISUAL MOTION

视觉运动的皮质处理

• 批准号: 3260780
• 负责人: William T Newsome
• 金额: $ 11.39万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-01-01 至 1987-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3260780
• 关键词: behavior test; brain mapping; eye movements; neural information processing; visual tracking

My long-term objective is to understand how neural processing in extrastriate visual cortex contributes to visual perception and visually guided behavior. The proposed research will focus on an extrastriate pathway in monkeys which is thought to be primarily involved in the analysis of visual motion. This pathway begins in striate cortex and continues through the Middle Temporal area (MT) and the Medial Superior Temporal area (MST) before reaching visuomotor regions of the parietal lobe that process information in more complex ways. Insight gained from these studies in rhesus monkeys may well be applicable to the human visual system since the visual and oculomotor capabilities of rhesus monkeys are known to be very similar to those of man. In addition, recent neurological findings suggest that a specific cortical pathway for visual motion exists in humans as well. Experiments will be carried out in awake, behaving monkeys trained to perform simple visuomotor and visual detection tasks. 1) Behavioral experiments will test the effects of chemical lesions of MT on a monkey's ability to detect visual motion and spatio-temporal contrast. This line of investigation should produce firm behavioral data concerning the functional role of MT in visual perceptions. 2) Physiological experiments will concentrate on a quantitative analysis of visual and visuomotor responses of single neurons in MST. Particular attention will be paid to neurons in MST which are known to fire in response to visual stimulation and in response to smooth pursuit eye movements. Interactions of these inputs will be examined, and the neural signals which drive the pursuit-related response will be studied. These experiments will complement previous studies of neuronal responses to visual motion in striate cortex, MT, and the parietal lobe, and will thus complete an initial physiological survey of this cortical motion pathway.

我的长期目标是了解神经处理如何 外层视觉皮层有助于视觉感知和视觉上 指导行为。 拟议的研究将重点放在外部 猴子中的途径被认为主要涉及 视觉运动的分析。 该途径始于条纹皮层和 继续穿过中间时间区域（MT）和中部上升 到达顶叶的视觉运动区域之前，时间区域（MST） 该处理信息以更复杂的方式。 从这些中获得的洞察力 在恒河猴中的研究很可能适用于人类视觉系统 由于已知恒河猴的视觉和动眼功能 与人类非常相似。 此外，最近的神经系统发现 提示人类中存在视觉运动的特定皮质途径 也是如此。 实验将在清醒中进行，行为训练的猴子 执行简单的视觉运动和视觉检测任务。 1）行为 实验将测试MT化学病变对猴子的影响 能够检测视觉运动和时空对比度。 这条线 调查应产生有关功能的公司行为数据 MT在视觉感知中的作用。 2）生理实验将 专注于视觉和视觉运动响应的定量分析 MST中的单个神经元。 特别注意神经元中的神经元 MST已知会响应视觉刺激和在 对光滑追击眼动的响应。 这些输入的相互作用 将检查和驱动与追踪有关的神经信号 响应将被研究。 这些实验将补充以前 对跨层皮质，MT和 顶叶，因此将完成初步的生理调查 该皮质运动途径的。