Gaze, Head Rotation, and Neuroanatomic Correlates of Reading Errors in Neglect Dyslexia

忽视阅读障碍中阅读错误的凝视、头部旋转和神经解剖学相关性

• 批准号: 10658715
• 负责人: Timothy John Rich
• 金额: $ 12.54万
• 依托单位: KESSLER FOUNDATION, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10658715
• 关键词: Activities of Daily Living; Affect; American; Applied Research; Area; Arousal; Attention; Basic Science; Behavior; Behavioral; Bilateral; Biometry; Brain; Brain Mapping; Brain scan; Classification; Clinical assessments; Cognition; Data; Detection; Diagnosis; Dorsal; Dyslexia; Etiology; Eye; Eye Movements; Face; Functional disorder; Funding; Goals; Head; Impairment; Individual; Intervention; Left; Leisures; Lesion; Letters; Literature; Location; Maps; Measures; Mentored Research Scientist Development Award; Modeling; National Institute of Child Health and Human Development; Neuroanatomy; Neurologic; Neuropsychology; Neurosciences Research; Outcome; Participant; Patients; Pattern; Play; Population; Positioning Attribute; Predictive Value; Reader; Reading; Reading Disorder; Rehabilitation therapy; Research; Role; Rotation; Side; Stimulus; Stroke; Symptoms; Technology; Training; United States National Institutes of Health; Visuospatial; Work; behavior test; cognitive neuroscience; experience; experimental study; functional gain; functional independence; gaze; improved; innovation; interest; neglect; nerve injury; neural network; neuroimaging; neurological rehabilitation; novel; post stroke; rehabilitation science; spatial neglect; stroke survivor; support network; treatment response; vigilance; virtual reality environment; visual stimulus; visual tracking

PROJECT SUMMARY/ABSTRACT Neglect dyslexia (ND) is an acquired reading disorder associated with spatial neglect (SN), commonly experienced by right hemisphere stroke survivors. ND causes whole-word omissions of left-sided words and errors on the left-sided letters of individual words (unilateral paralexias). These two distinct error types can be explained by dysfunctional egocentric (i.e., viewer-centered) and allocentric (i.e., object-centered) spatial cognition, respectively. Gaze asymmetry has long been considered a hallmark symptom of SN, and recent research suggests that it might contribute to these errors. However, no study to date has directly correlated gaze and reading in this population. Gaze involves the coordination of the head and eyes to orient toward a target. However, most gaze-related research in SN and ND thus far has required the head to be stabilized at midline. Therefore, relative contributions of the head and eyes to the asymmetry of gaze in SN and ND is unknown. Current neuroanatomical models of SN and ND suggest that it is caused by disruptions to the interaction of a bilateral dorsal attention network, which subserves spatial attention and eye movements, and a unilateral right hemisphere ventral attention network, which supports arousal, vigilance, detection of novel stimuli, and reorienting attention to novel stimuli. It is unknown how a network disruption leads to a specific type of ND. In this project, we will examine the predictive value of gaze on ND reading errors, the relative contributions of the head and eyes to gaze orientation, and the disrupted neural networks that underlie specific gaze patterns and egocentric and allocentric ND error patterns. (1) To characterize the association between gaze and reading, we will conduct two experiments that measure gaze with a wearable eye tracker during single-word reading. We expect to find a strong correlative relationship between gaze accuracy and reading accuracy in participants with ND, which would support the potential for the use of gaze metrics for ND diagnosis and classification. (2) To determine the relative contributions of the head and eyes to gaze deficits, we will conduct an experiment using eye tracking-enabled immersive virtual reality to measure gaze while manipulating the effect of head rotation. We expect participants with a greater contribution of the head to have poorer egocentric gaze toward left-sided words and more whole-word omissions. (3) To identify the neural networks that underlie gaze asymmetry and reading errors, we will lesion map brain scans of participants with and without ND, then use voxel-wise lesion- symptom mapping to correlate the degree of lesioned brain areas to gaze accuracy and reading accuracy. We anticipate that lesions disrupting the dorsal network impair egocentric gaze orientation and associate with whole- word omissions, and that lesions disrupting the ventral network impair allocentric gaze orientation and associate with unilateral paralexias.

项目概要/摘要 忽视阅读障碍（ND）是一种与空间忽视（SN）相关的获得性阅读障碍，通常 右半球中风幸存者所经历的。 ND 会导致左侧单词的整个单词遗漏，并且 个别单词左侧字母错误（单侧偏读）。这两种不同的错误类型可以是 通过功能失调的自我中心（即以观看者为中心）和异中心（即以对象为中心）空间来解释 分别认知。长期以来，视线不对称一直被认为是 SN 的标志症状，最近 研究表明它可能会导致这些错误。然而，迄今为止，还没有研究将凝视与凝视直接相关。 以及这个人群的阅读情况。凝视涉及头部和眼睛的协调以朝向目标。 然而，迄今为止，大多数 SN 和 ND 中与凝视相关的研究都要求头部稳定在中线。 因此，头部和眼睛对 SN 和 ND 中注视不对称性的相对贡献是未知的。 目前 SN 和 ND 的神经解剖模型表明，它是由 SN 和 ND 之间的相互作用中断引起的。 双边背侧注意力网络，促进空间注意力和眼球运动，以及单侧右侧注意力网络 半球腹侧注意力网络，支持唤醒、警惕、新刺激的检测，以及 重新调整对新刺激的注意力。目前尚不清楚网络中断如何导致特定类型的 ND。在 在这个项目中，我们将研究凝视对 ND 读数误差的预测价值、 头部和眼睛到凝视方向，以及特定凝视模式和基础的神经网络被破坏 自我中心和非中心 ND 错误模式。 (1) 为了描述凝视和阅读之间的关联，我们 将进行两项实验，在单字阅读过程中使用可穿戴眼动仪测量凝视。我们 期望在患有以下疾病的参与者中发现凝视准确性和阅读准确性之间存在很强的相关关系 ND，这将支持使用注视指标进行 ND 诊断和分类的潜力。 (2) 至 为了确定头部和眼睛对凝视缺陷的相对贡献，我们将使用 支持眼球追踪的沉浸式虚拟现实可以在操纵头部旋转效果的同时测量注视。 我们预计头部贡献较大的参与者对左侧的自我中心目光会较差 词和更多的全词遗漏。 (3) 识别凝视不对称背后的神经网络 阅读错误，我们将对有或没有 ND 的参与者进行脑部扫描，然后使用体素损伤- 症状映射将受损大脑区域的程度与凝视准确性和阅读准确性相关联。我们 预计破坏背侧网络的病变会损害以自我为中心的凝视方向并与整体相关 单词遗漏，并且破坏腹侧网络的病变损害异中心凝视方向和联想 伴有单侧偏读症。