NeuroMAP Phase II - Circuits and Molecules Core

NeuroMAP II 期 - 电路和分子核心

• 批准号: 10711137
• 负责人: Jonathan Savitz
• 金额: $ 44.63万
• 依托单位: LAUREATE INSTITUTE FOR BRAIN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10711137
• 关键词: Acceleration; Affect; Anxiety Disorders; Applications Grants; Area; Arkansas; Astrocytes; Award; Behavior; Biological; Blood specimen; Brain; Businesses; Cities; Common Core; Data; Data Analyses; Data Element; Data Set; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Ensure; Environment; Equilibrium; Extramural Activities; Fee-for-Service Plans; Formulation; Functional Magnetic Resonance Imaging; Functional disorder; Future; Geographic Locations; Goals; Grant; Health Sciences; Hospitals; Human; Image; Immunology; Individual; Inflammation Mediators; Inflammatory; Infrastructure; Interoception; Laboratories; Laboratory Procedures; Link; Magnetic Resonance Imaging; Measurement; Measures; Mental Health; Metabolic Marker; Metabolism; MicroRNAs; Molecular; Molecular Biology; Mood Disorders; Motivation; Myelin; National Institute of Mental Health; Negative Valence; Neurons; Neurosciences; Oklahoma; Paper; Participant; Phase; Pilot Projects; Positive Valence; Process; Proteins; Publications; Research; Research Domain Criteria; Research Personnel; Research Project Grants; Research Support; Resources; Rest; Sampling; Services; Signal Transduction; Stimulus; Structure; System; Testing; Thinking; Time; Universities; Update; Validation; Work; approach behavior; base; cost; cost estimate; data management; extracellular vesicles; health assessment; laboratory equipment; motivated behavior; neural circuit; neuroimaging; neuroinflammation; reconstruction; recruit; response; statistics; success

PROJECT SUMMARY: Circuits and Molecules Core The Circuits and Molecules (C&M) Core of the Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP) in Phase II will support Research Project Leaders (RPLs) and Pilot Project Investigators (PPIs) by overseeing the acquisition, storage, and analysis of biological samples and neuroimaging data. The first goal of the C&M Core is to accelerate the RPL and PPI projects by (a) providing the necessary expertise in neuroimaging and molecular biology to ensure the success of NeuroMAP projects and (b) aiding in the formulation of new aims and hypotheses based on common core data elements (CDE) to make R-level grant applications more competitive. The second goal of C&M Core is to develop self-sufficiency so that it can ultimately serve as a resource for the broader geographical region. To achieve this goal, the C&M Core will develop a detailed business plan with cost estimates to support sustainability beyond the CoBRE. The C&M Core will work together with the Recruitment and Assessment Core and the Data Management and Statistics Core to support the NeuroMAP theme: the identification and validation, via an experimental approach, of targetable disease-modifying processes (DMPs) in mood and anxiety disorders. During Phase I, a set of CDE was established across all projects and provided a balance between the research goals of the individual RPL projects and secondary data analyses for PPIs. During that Phase, more than 350 neuroimaging assessments were obtained consisting of a standard structural MRI, diffusion tensor imaging, a resting state MRI, and several functional MRI tasks. Similarly, blood samples from over 350 participants were collected to measure a range of circulating inflammatory mediators. In Phase II, the C&M Core will work with the Recruitment and Assessment Core to collect a new imaging and laboratory data set that can be used by RPLs to extend their projects and PPIs to identify new DMPs. The imaging and laboratory measures were selected to delineate process dysfunctions by individuals with mood and anxiety disorders in the (a) Negative Valence domain i.e., how individuals respond to aversive contexts, (b) Positive Valence domain i.e., how individuals respond to positive contexts and (c) Interoception domain i.e., the processing of internal bodily signals to affect behavior. These measures will be optimized in Phase II. Advanced sequences to measure myelin content and neuroinflammation (restricted diffusion imaging) will be added to the Circuit component while the Molecules component will focus on the measurement of microRNA and proteins from astrocyte- enriched extracellular vesicles (EVs), building on our recent publications in this area. The C&M Core will be led by Co-Directors, Drs. Rohan and Savitz with the support of Ms. Arterbury and Drs. Burrows and Misaki. Drs. Savitz and Burrows (molecules component) will also liaise closely with Dr. Teague, director of the Integrative Immunology Center at the University of Oklahoma.

项目摘要：电路和分子核心 基于神经科学的心理健康评估中心的电路和分子 (C&M) 核心 第二阶段的预测 (NeuroMAP) 将支持研究项目负责人 (RPL) 和试点项目 研究人员 (PPI) 通过监督生物样本的采集、储存和分析， 神经影像数据。 C&M 核心的首要目标是通过 (a) 提供来加速 RPL 和 PPI 项目 神经影像和分子生物学方面必要的专业知识，以确保 NeuroMAP 项目的成功 (b) 帮助根据共同核心数据元素（CDE）制定新的目标和假设，以 使 R 级资助申请更具竞争力。 C&M Core的第二个目标是发展自给自足 以便它最终能够成为更广泛地理区域的资源。为了实现这一目标，C&M Core 将制定详细的业务计划和成本估算，以支持 CoBRE 之外的可持续性。 C&M 核心将与招聘和评估核心以及数据管理和 支持 NeuroMAP 主题的统计核心：通过实验进行识别和验证 情绪和焦虑症的有针对性的疾病缓解过程（DMP）的方法。在第一阶段， 所有项目都建立了一套 CDE，并在各个项目的研究目标之间提供了平衡 单独的 RPL 项目和 PPI 的二次数据分析。在此阶段，超过 350 神经影像评估包括标准结构 MRI、扩散张量成像、 静息态 MRI 和一些功能性 MRI 任务。同样，来自 350 多名参与者的血液样本被 收集来测量一系列循环炎症介质。在第二阶段，C&M Core 将与 招募和评估核心收集新的成像和实验室数据集，供以下人员使用 RPL 扩展其项目，PPI 确定新的 DMP。影像学和实验室测量是 选择描述患有情绪和焦虑症的个体的过程功能障碍（a）消极 价域，即个体如何应对厌恶的环境，（b）正价域，即如何 个人对积极环境做出反应，以及（c）内感受域，即内部身体的处理 影响行为的信号。这些措施将在第二阶段进行优化。高级测量序列 髓磷脂含量和神经炎症（限制扩散成像）将添加到电路组件中 而分子部分将重点关注星形胶质细胞中的 microRNA 和蛋白质的测量 丰富的细胞外囊泡（EV），建立在我们最近在该领域发表的出版物的基础上。 C&M 核心将由 由联合董事，博士。罗汉和萨维茨在阿特伯里女士和博士的支持下。布罗斯和美咲。博士。 Savitz 和 Burrows（分子部分）还将与综合中心主任 Teague 博士密切联系 俄克拉荷马大学免疫学中心。