ORGANIZATION OF EXTRASTRIATE VISUAL CORTEX

外纹视觉皮层的组织

• 批准号: 3259375
• 负责人: Helen A. Sherk
• 金额: $ 9.2万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-07-01 至 1992-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3259375
• 关键词: autoradiography; axon; brain mapping; cats; experimental brain lesion; histology; innervation; laboratory rat; neural information processing; neuroanatomy; single cell analysis; stimulus /response; tritium; visual cortex; visual feedback; visual fields; visual pathways; visual stimulus

The goal of the proposed work is to investigate a large region of extrastriate visual cortex in the cat, the Clare-Bishop area. Its internal organization will be studied, and its relationship with three other areas of visual cortex, areas 17, 18, and 19. The Clare-Bishop area is of particular interest because it might be considered the "highest-order" of the 3 visual areas that receive input from areas 17. Its response properties bear the least resemblence to those of area 17; it is unique in having major input from a zone of thalamus connected to the superior colliculus; and it receives only weak input from the lateral geniculate nucleus. The Clare-Bishop area appears to differ from areas 17, 18, and 19 in another fundamental way. Its map of the upper visual field is complex and redundant. It is logical to ask whether Clare- Bishop's map of the lower visual field is similarly organized. If it also is redundant, one might suspect that this kind of mapping is characteristic of higher-order visual cortex, and will be found in other areas. Almost nothing is known about other kinds of functional organization present in the Clare-Bishop area. Thus a major goal is to investigate whether it is compartmentalized according to particular response properties. Some possibilities are orientation preference, selectivity for stimulus distance, and selectivity for movement in depth. The third focus of this proposal concerns the ordering of connections between the Clare-Bishop area and primary visual cortex. In tracer experiments, labeled cells in area 17 that send axons to Clare-Bishop tend to be clustered. The functional basis of this clustering will be examined. It might relate to functional compartmentalization within the Clare-Bishop area, such that matching compartments in area 17 and Clare-Bishop are connected, while ones with opposite response properties are not. Alternatively, clustering might be an intrinsic characteristic of the cell population in area 17 projecting to the Clare-Bishop area. If so, it is possible that the regions lacking projections to Clare- Bishop send axons instead to either area 18 or area 19. If such regions are found, the possibility that they also have distinctive response properties will be examined.

拟议工作的目的是调查 猫（Clare-Bishop）区域的猫外视觉皮层外皮层。 它是 内部组织将被研究及其与 其他三个视觉皮层区域，区域17、18和19。 克莱尔 - 主教区域特别感兴趣，因为它可能是 被认为是接收的3个视觉区域中的“最高级别” 17区域的输入。其响应特性最少 与17区的相似之处；它在获得主要投入方面是独一无二的 从连接到上丘的丘脑区域。和 它仅收到侧向元素核的弱输入。 Clare-Bishop地区似乎与17、18和19区不同 以另一种基本方式。 它的上部视野图是 复杂而多余。 询问克莱尔是否是合乎逻辑的 - Bishop的下部视野地图类似地组织了。 如果是 也是多余的，可能会怀疑这种映射是 高阶视觉皮层的特征，将在 其他领域。 关于其他功能几乎一无所知 组织在克莱尔 - 主教地区。 因此一个主要目标 是根据根据 特定的响应属性。 一些可能性是定向 偏好，刺激距离的选择性和选择性 深入运动。 该提案的第三个重点涉及 克莱尔 - 主 - 区域与主要视觉的连接 皮质。 在示踪剂实验中，在17区的区域标记了细胞 轴突到clare-bishop倾向于聚集。 功能基础 将检查此聚类。 它可能与功能有关 克莱尔 - 主教区域内的隔间化，以便 区域17和克莱尔 - 主教的匹配室是 连接，而具有相反响应属性的连接却没有。 或者，聚类可能是 第17区的细胞人群投射到克莱尔 - 主教区域。 如果是这样，那么可能缺乏clare预测的地区 主教将轴突转到第18区或区域19。如果这样 发现区域，它们也具有独特的可能性 将检查响应属性。