DETERMINANTS OF OPTIC AXON OUTGROWTH

视轴突生长的决定因素

• 批准号: 3260323
• 负责人: RAYMOND D LUND
• 金额: $ 15.24万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-03-01 至 1996-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3260323
• 关键词: antiantibody; axon; developmental neurobiology; embryo /fetus; eye transplantation; fluorescence microscopy; histology; immunocytochemistry; inferior colliculus; laboratory mouse; laboratory rat; laminin; nervous system regeneration; neural cell adhesion molecules; neurogenesis; neuronal guidance; optic tract; phase contrast microscopy; polylysine; retinal ganglion; superior colliculus; synaptogenesis; tissue /cell culture; video recording system

DESCRIPTION (Investigator's Abstract): The applicants plan to study conditions in the developing rodent brain necessary for supporting optic axon outgrowth and for establishing appropriate terminal connections between molecules known to support axonal outgrowth and the extension of retinal ganglion cell axons. In addition, the applicants will examine the conditions that produce optimal outgrowth and formation of connections by retinae transplanted to ectopic sites in neonatal and fetal rodent brains. One series of studies will focus on the outgrowth process itself and the substrates that support it while the other will examine what factors influence the ability of optic axons originating from transplants to innervate visual centers, to compete with other optic inputs for target space and to form topographic maps within visual centers. Such information will provide insight into how the circuitry for optimal visual function is established. It will also define the conditions necessary for creating surrogate pathways to replace damaged primary optic connections.

描述（研究者的摘要）：申请人计划学习 支持光学所需的发育中啮齿动物大脑的条件 轴突的生长和建立适当的终端连接 在已知的分子之间支持轴突生长和延伸 视网膜神经节细胞轴突。 此外，申请人将检查 通过 视网膜移植到新生儿和胎儿啮齿动物大脑中的异位部位。 一系列研究将侧重于产物生长过程本身和 支持它的底物，而另一个将检查哪些因素 影响源自移植到移植到的光轴突的能力 支配视觉中心，以与其他光学输入竞争目标 空间并在视觉中心内形成地形图。 此类信息将洞悉如何最佳电路 建立了视觉功能。 它也将定义条件 创建替代损坏的主要光学元件所需的替代途径所需的必要 连接。