Highly Accelerated Simultaneous Multi-Slice Phase Contrast MRI

高加速同步多层相衬 MRI

• 批准号: 9322305
• 负责人: David Alan Feinberg
• 金额: $ 136.91万
• 依托单位: ADVANCED MRI TECHNOLOGY, LLC
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9322305
• 关键词: Acceleration; Algorithms; Aorta; Basic Science; Biological Markers; Blood; Blood Vessels; Blood flow; Brain Diseases; California; Cardiac; Cardiovascular Diseases; Cardiovascular system; Carotid Arteries; Cerebrovascular Disorders; Cerebrum; Circle of Willis; Clinical; Clinical Research; Computer software; Coronary artery; Data Set; Development; Diagnosis; Diagnostic; Dimensions; Disease; Europe; Family; Financial compensation; Functional Imaging; Future; Gold; Heart Diseases; Heart Rate; Hospitals; Human body; Image; Imaging Techniques; Imaging technology; London; Magnetic Resonance Imaging; Manuals; Manufacturer Name; Measurement; Measures; Medical; Medical Research; Medical center; Morphologic artifacts; Motion; Neurosciences Research; Output; Patients; Performance; Perfusion; Pharmacotherapy; Phase; Physiologic pulse; Physiological; Protocols documentation; Radial; Research Personnel; Resolution; Sampling; San Francisco; Scanning; Scheme; Sensitivity and Specificity; Site; Slice; Speed; Stroke; Techniques; Technology; Testing; Time; Universities; Variant; cerebrospinal fluid flow; clinical Diagnosis; contrast imaging; data acquisition; design; graphical user interface; hemodynamics; image reconstruction; imaging approach; improved; innovation; medical schools; neurovascular; new technology; novel; novel therapeutics; public health relevance; quantitative imaging; reconstruction; research clinical testing; respiratory; temporal measurement; time interval; tool; vertebral artery

 DESCRIPTION (provided by applicant): MRI phase contrast velocity imaging is a widely disseminated on nearly all MRI scanners used for clinical diagnosis of brain disease, cardiac and cardiovascular disease and for neuroscience research. Currently phase contrast imaging of blood flow and CSF motion requires longer scan times with each 2D slice or 3D spatial image requiring additional dimension of velocity encoding requiring greater acquisition time. Given the physiological variation in heart rate, cardiac stroke output and respiratory motion effects on blood and CSF velocity, no less the need to greatly reduce the patients time in the scanner, there is a need to reduce the scan time of phase contrast imaging. To achieve several times faster imaging we propose to develop novel technology to acquire velocity phase images simultaneously instead of seperately. Our new technique called simultaneous multi-slice imaging (SMS) phase contrast (PC) imaging is innovated to obtain 2 -10 phase contrast images recorded simultaneously resulting in nearly this factor of reciprocal reduction in scan time. The availability of the new simultaneous phase contrast imaging technology will give clinicians and researchers the capability of performing significantly improved MRI perfusion measurements in the and these improvements will impact the diagnosis of many different diseases, including stroke, cardiac, cardiovascular diseases. Additionally blood flow and CSF flows which are important quantitative biomarkers useful as physiological imaging in evaluating new drug therapies for diseases. This family of new phase contrast imaging techniques utilizes more efficient pulse sequences that provide major advantages in resolution, slice coverage, SNR and speed. The new simultaneous imaging will have high utility and be highly desirable for use on clinical scanners worldwide. The improved quantitative MRI blood flow imaging offers overall increased speed that is highly commercializable given they provide improved diagnostic approaches to evaluate diseases and further improve specificity and sensitivity in MRI exams. The new technology will be designed, implemented and evaluated on MRI scanners at University of California Berkeley, University of California San Francisco (UCSF) Medical Center, Harvard Medical School, and Cedar-Sinai Medical Center. Once imaging protocols are optimized they will be further evaluated and optimized in collaborative clinical test sites in Europe, including the major cardiovascular hospital in London, the Royal Brompton Hospital and elsewhere. In addition to establishing their value in medical exams, the simultaneous phase contrast imaging will be made into useful tools for basic and clinical research.

 描述（由申请人提供）：MRI相衬速度成像广泛应用于几乎所有用于脑部疾病、心脏和心血管疾病的临床诊断以及神经科学研究的MRI扫描仪上，目前血流和脑脊液运动的相衬成像需要更长的时间。每个 2D 切片或 3D 空间图像的扫描时间需要额外的速度编码维度，需要更长的采集时间。考虑到心率、心搏输出量和呼吸运动对血液和脑脊液速度的影响，同样需要大大减少。为了减少患者在扫描仪中的时间，需要减少相差成像的扫描时间，我们建议开发新技术来同时获取速度相位图像，而不是单独获取。切片成像 (SMS) 相衬 (PC) 成像经过创新，可以获得同时记录的 2 -10 个相衬图像，从而大大减少了扫描时间。新的同步相​​衬成像技术的可用性将为新教徒和研究人员提供便利。执行能力显着提高MRI 灌注测量的这些改进将影响许多不同疾病的诊断，包括中风、心脏病、心血管疾病。另外，血流量和脑脊液流量是重要的定量生物标志物，可用作评估该家族疾病的新药物疗法的生理成像。新的相衬成像技术利用更高效的脉冲序列，在分辨率、切片覆盖范围、信噪比和速度方面具有很大的优势，新的同步成像将具有很高的实用性，非常适合在全球临床扫描仪上使用。成像提供整体提高的速度鉴于它们提供了改进的诊断方法来评估疾病并进一步提高 MRI 检查的特异性和敏感性，这项新技术将在加州大学伯克利分校、加州大学旧金山分校 (UCSF) 医学中心的 MRI 扫描仪上进行设计、实施和评估。哈佛医学院和雪松-西奈医疗中心一旦优化成像方案，将在欧洲的合作临床测试地点进行进一步评估和优化，其中包括伦敦的主要心血管医院、皇家布朗普顿医院和其他地方。它们的医学价值考试中，同步相差成像将成为基础和临床研究的有用工具。

项目成果

The effect of continuous positive airway pressure on total cerebral blood flow in healthy awake volunteers.

持续气道正压通气对健康清醒志愿者脑总血流量的影响。

• 发表时间: 2013-03
• 作者: Yiallourou, Theresia I;Odier, Céline;Heinzer, Raphael;Hirt, Lorenz;Martin, Bryn A;Stergiopulos, Nikolaos;Haba
• 通讯作者: Haba