NEURAL EFFECTS OF LOW-LEVEL MICROWAVES

低强度微波对神经的影响

• 批准号: 3251281
• 负责人: HENRY C LAI
• 金额: $ 21.34万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-01 至 1996-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3251281
• 关键词: acetylcholine; behavior; biochemistry; brain; cholinergic receptors; corticotropin releasing factor; heat; histology; laboratory rat; learning disorders; microwave radiation; muscarinic receptor; neurochemistry; neuropharmacology; neurophysiology; neuropsychology; opioid receptor; radiation hazard; radiobiology

The applicants propose experiments to further investigate the neural mechanisms involved in the neurological effects of low-level microwave irradiation in the rat. In previous research, the applicants found that acute low-level microwave exposure changed the activity of the cholinergic systems in the rat brain, and after repeated exposure, changes occurred in the muscarinic cholinergic receptors. Furthermore, the applicants found that the effects were mediated by endogenous opioids and corticotropin- releasing factor (CRF) in the brain. To further study the neural mechanisms involved, this proposal has the following objectives: 1) to reveal the subtypes of muscarinic cholinergic receptors (M1 and M2) in the brain affected by low-level microwaves; 2) to investigate the subtypes of endogenous opioid receptors (i.e., mu, delta, and kappa) and the loci in the brain where they mediate the microwave-induced changes in cholinergic activity; and to study the possible changes in opioid receptors in the brain after repeated microwave exposure and 3) to determine the location in the brain where CRF mediates the microwave-induced changes in central cholinergic activity. In addition, since the applicant has also found that low-level microwave irradiation affects spatial learning and memory functions, further experiments are proposed to study the neural mechanisms involved in the learning deficient.

申请人提出实验以进一步研究神经 低级微波炉的神经系统作用涉及的机制 大鼠的照射。 在先前的研究中，申请人发现 急性低级微波暴露改变了胆碱能的活性 大鼠大脑中的系统以及反复接触后，发生了变化 毒蕈碱胆碱能受体。 此外，发现申请人 该作用是由内源性阿片类药物和皮质激素 - 大脑中释放因子（CRF）。 进一步研究神经 涉及的机制，该提议具有以下目标：1） 揭示毒蕈碱胆碱能受体（M1和M2）的亚型 大脑受低级微波影响； 2）调查亚型 内源性阿片受体（即Mu，Delta和Kappa）和位点 它们介导微波诱导的胆碱能变化的大脑 活动;并研究阿片受体的可能变化 重复微波暴露后的大脑和3）确定位置 CRF介导微波诱导的中央变化的大脑 胆碱能活性。 此外，由于申请人还发现 低级微波辐射会影响空间学习和记忆 提出了功能，提出了进一步的实验来研究神经机制 参与学习不足。