CANCER INCIDENCE ASSOCIATED WITH AMBIENT AIR POLLUTION

癌症发病率与环境空气污染有关

• 批准号: 3254650
• 负责人: PAUL K MILLS
• 金额: $ 12.77万
• 依托单位: LOMA LINDA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-04-07 至 1996-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3254650
• 关键词: air pollution; cancer information system; cancer registry /resource; cancer risk; environment related neoplasm /cancer; female; gender difference; human data; human mortality; interview; longitudinal human study; mathematical model; medical records; occupational hazard; ozone; passive smoking; pollutant interaction; questionnaires; respiratory neoplasm

In the proposed study the association between long-term cumulative levels of ambient air pollutants and cancer incidence in a population of non-smoking California Seventh-day Adventists will be evaluated. Specifically, the association between total suspended particulates, fine particulate matter and ozone will be evaluated in regard to their association with newly diagnosed respiratory cancer and all cancer sites combined in a population of six thousand Adventists residing in urban areas of California. Cancer incidence and mortality data are already available for the time period 1977-1982 and data on long-term cumulative levels of the ambient air pollutants are available for the period 1966-1986. The results of analysis to date indicate statistically significant elevations in cancer risk among females associated with the higher levels of TSP (1). No funding is currently available to update cancer incidence or mortality data on the cohort beyond 1983. Therefore, this application seeks funding to 1) update cancer incidence and mortality, 1983-1991, through computerized record linkage with the population-based tumor registries in California (1983-1987) and through record linkage with the California Tumor Registry 1988-1991 and the 2) ascertain cancer incidence by mail and telephone contact and by review of medical records among study members not residing in tumor registry areas and to 3) trace and contact next-of-kin of deceased study participants to obtain updated residential history information and information on occupational exposures and exposures to passive smoke and 4) to conduct an in-depth analysis of the association between long-term ambient levels of air pollution and cancer incidence taking into account potentially confounding variables such as age, sex, education, exposure to passive smoke and air-borne occupational air contaminants. Also adjustments will be made for the time spent indoors.

在拟议的研究中，长期累积水平之间的关联 人群中的环境空气污染物和癌症发病率 将评估非吸烟的加利福尼亚基督复临安息日会。 具体而言，总悬浮颗粒之间的关联，罚款 颗粒物和臭氧将根据其评估 与新诊断的呼吸癌和所有癌症部位的关联 居住在城市 加利福尼亚地区。 癌症发病率和死亡率数据已经有时间 1977 - 1982年期间以及有关环境的长期累积水平的数据 空气污染物可在1966 - 1986年期间使用。 结果 迄今为止的分析表明癌症的统计显着升高 与较高水平的TSP相关的女性的风险（1）。 目前尚无资金来更新癌症的发病率或死亡率 因此，关于1983年以后的队列数据。 1）通过 计算机记录与基于人群的肿瘤注册处的联系 加利福尼亚（1983-1987），并通过与加利福尼亚的记录联系 肿瘤注册表1988-1991和2）通过邮件确定癌症发病率 和电话联系以及研究中的病历 成员不居住在肿瘤注册表区域，到3）跟踪和接触 死者研究参与者的临近人获得更新的住宅 历史信息和有关职业暴露和信息的信息 暴露于被动烟雾和4）对 长期环境水平的空气污染与癌症之间的关联 考虑到可能混淆变量的发病率，例如 年龄，性别，教育，被动烟雾和空中的职业 空气污染物。 还将在花费的时间进行调整 在室内。