Cancer Incidence and Mortality in California Farmworkers

加州农场工人的癌症发病率和死亡率

• 批准号: 6755105
• 负责人: PAUL K MILLS
• 金额: $ 19.58万
• 依托单位: PUBLIC HEALTH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-06 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6755105
• 关键词: Hispanic Americans; agriculture worker; brain neoplasms; cancer registry /resource; cancer risk; cervix neoplasms; clinical research; environment related neoplasm /cancer; environmental exposure; human data; human morbidity; human mortality; leukemia; neoplasm /cancer diagnosis; neoplasm /cancer epidemiology; occupational disease /disorder; pesticides; stomach neoplasms

DESCRIPTION (provided by applicant): The broad objectives of the proposed research are to measure cancer incidence and mortality in a cohort of farm workers in California (N=139,000) and to conduct nested case-control studies within the cohort in order to evaluate the association between work involving pesticide exposures and cancer risk. The objectives of this study will be accomplished using a variety of epidemiologic study designs. A computerized record linkage will be conducted between a roster of a largely Hispanic farm worker union (the United Farm Workers of America or the UFW) and the database of the California Cancer Registry (CCR) the population-based cancer registry which has monitored cancer incidence and mortality in California since 1988. Upon completion of the record linkages for both newly diagnosed cancers (1988-2000) and cancer deaths (1973-2000), risk of cancer for specific types of cancer will be evaluated in the UFW by calculating morbidity/mortality odds ratios using the California Hispanic population as the reference. In addition, variables such as stage and grade of disease at diagnosis, and histologic subtype of cancer will be evaluated, again comparing the experience of UFW members with cancer to the cancer experience of the California Hispanic population. After completion of the initial descriptive analyses, nested case-control studies will be conducted for several types of cancer including leukemia, brain, stomach and cervix cancer. Specifically, for each cancer case diagnosed among the membership of the UFW, incidence density controls will be selected form the remainder of the cohort. Occupational histories, including the nature of the crops and commodities in which individual cases and controls worked will be used as the exposure variables of interest. Data from the California Department of Pesticide Regulation (DPR) will also be used to construct lob exposure matrices (JEM) for both cases and controls. Adjusted odds ratios will be calculated for several cancer sites evaluating particular pesticide exposure profiles as well as length of work in particular crops and commodities. Survival analyses will also be completed comparing the five-year relative survival of cancer in the UFW to the California Hispanic population.

描述（由申请人提供）：拟议研究的广泛目标是衡量加利福尼亚州的农场工人队列中的癌症发病率和死亡率（n = 139,000），并在同类中进行嵌套的病例对照研究，以评估涉及农药暴露企业和癌症风险的工作之间的关联。 这项研究的目标将使用各种流行病学研究设计实现。 A computerized record linkage will be conducted between a roster of a largely Hispanic farm worker union (the United Farm Workers of America or the UFW) and the database of the California Cancer Registry (CCR) the population-based cancer registry which has monitored cancer incidence and mortality in California since 1988. Upon completion of the record linkages for both newly diagnosed cancers (1988-2000) and cancer deaths (1973-2000), risk of cancer for specific通过使用加利福尼亚西班牙裔人群来计算发病率/死亡率比率，将在UFW中评估癌症的类型。此外，还将评估诊断阶段和疾病等级的变量，以及癌症的组织学亚型，再次将UFW成员的癌症成员与加利福尼亚西班牙裔人群的癌症经历进行比较。 最初的描述性分析完成后，将针对多种类型的白血病，脑，胃和子宫颈癌进行嵌套的病例对照研究。具体而言，对于在UFW成员中诊断出的每种癌症病例，将选择发病率密度控制措施。职业历史，包括农作物和商品的性质，其中有效的单个病例和控制将被用作感兴趣的暴露变量。加利福尼亚州农药调节部（DPR）的数据也将用于构建病例和对照组的LOB暴露矩阵（JEM）。调整后的优势比将用于评估特定农药暴露概况以及特定农作物和商品的工作时间的几个癌症部位。将UFW癌症的五年相对生存与加利福尼亚西班牙裔人口进行比较，还将完成生存分析。