Enzymic polymerisation, characterisation and market evaluation of a set of novel bioplastic co-polymers derived from renewable resources

一系列源自可再生资源的新型生物塑料共聚物的酶聚合、表征和市场评估

• 批准号: BB/N023595/1
• 负责人: James Clark
• 金额: $ 38.72万
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FN023595%2F1
• 关键词: Enzymic; polymerisation; characterisation; market; evaluation

Plastics are produced on an enormous scale, both within the UK and globally, and are used in functional products all around us. The vast majority of plastics are currently produced from no-renewable depleting fossil resources, predominately crude oil. There has been recent widespread research into the conversion of sustainable and renewable biomass to monomers and polymers, ideally looking to utilise the most abundant form of waste biomass, lignocellulose. Biome's (company lead) overall strategy is to produce novel highly functional polyesters from this lignocellulose by using industrial biotechnology. This project with the Universities of York and Liverpool will take lignocellulose-derived aromatic diacids (monomers) and utilise enzymes in a multi-step polymerisation to produce a targeted group of novel copolymers and explore their properties. The project will also determine whether this biocatalysis can be undertaken in-situ of the diacid production and will provide quantities of bio-derived plastics to be assessed for their potential in high value markets, and will also demonstrate the capability of the bio-catalytic reactions to be scaled to >1 kg. Previous work (supported by Innovate UK) has already demonstrated that the aromatic diacids can be produced from both lignin and cellulose using both engineered bacteria/enzymes and a scale-up for diacid formation is already underway. These diacids have already been used to make the first small quantities of novel polyester copolymers (with exciting preliminary properties), prompting this project application. This project will additionally contribute to the development of these novel bio-derived polymers through the assessment of induced chain-branching, thus altering their physical properties and eventual application. It will also undertake initial investigations into the end-of-life options for these polymers, including breaking them back down to monomer units, ensuring that after product use their environmental footprint will be minimised.

塑料是在英国和全球范围内的巨大规模生产的，并在我们周围的功能产品中使用。绝大多数塑料目前是由无可再生的化石资源（主要是原油）产生的。最近，关于将可持续和可再生生物量转化为单体和聚合物的转化，理想情况下，人们一直在广泛研究，希望利用最丰富的废物生物量木质纤维素。 Biome（公司负责人）的总体策略是使用工业生物技术从该木质纤维素中生产出新型的高度功能性聚酯。该项目与约克大学和利物浦大学一起采用木质纤维素衍生的芳族二氧化氨纤维（单体），并在多步聚合中利用酶来产生目标的新型共聚物并探索其性质。该项目还将确定是否可以在二肽生产的原位进行这种生物催化，并将提供数量的生物衍生塑料，以评估其在高价值市场中的潜力，还将证明生物催化反应的能力以缩放到> 1 kg。先前的工作（由Innovate UK的支持）已经证明，使用工程细菌/酶可以从木质素和纤维素中生产芳香族二肽，并且已经在进行二氨基形成量表。这些二芯已经被用来制造第一次新型聚酯共聚物（具有令人兴奋的初步特性），从而促使此项目应用。该项目还将通过评估诱导的链分支，从而改变了它们的物理特性和最终应用，从而为这些新型生物衍生的聚合物的发展做出贡献。它还将对这些聚合物的寿命终止选择进行初步调查，包括将它们重新放回单体单元，以确保产品后使用其环境足迹将被最小化。

项目成果

Effects of Methyl Branching on the Properties and Performance of Furandioate-Adipate Copolyesters of Bio-Based Secondary Diols.

• DOI: 10.1021/acssuschemeng.0c04513
• 发表时间: 2020-09-28
• 期刊: ACS sustainable chemistry & engineering
• 影响因子: 8.4
• 作者: Little A;Pellis A;Comerford JW;Naranjo-Valles E;Hafezi N;Mascal M;Farmer TJ
• 通讯作者: Farmer TJ

Elucidating enzymatic polymerisations: Chain-length selectivity of Candida antarctica lipase B towards various aliphatic diols and dicarboxylic acid diesters

• DOI: 10.1016/j.eurpolymj.2018.07.009
• 发表时间: 2018-09-01
• 期刊: EUROPEAN POLYMER JOURNAL
• 影响因子: 6
• 作者: Pellis, Alessandro;Comerford, James W.;Farmer, Thomas J.
• 通讯作者: Farmer, Thomas J.

Enzymatic synthesis of unsaturated polyesters: functionalization and reversibility of the aza-Michael addition of pendants

• DOI: 10.1039/c8py01655k
• 发表时间: 2019-02-21
• 期刊: POLYMER CHEMISTRY
• 影响因子: 4.6
• 作者: Pellis, Alessandro;Hanson, Polly Ann;Farmer, Thomas J.
• 通讯作者: Farmer, Thomas J.

Enzymatic synthesis of lignin derivable pyridine based polyesters for the substitution of petroleum derived plastics

• DOI: 10.1038/s41467-019-09817-3
• 发表时间: 2019-04-16
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Pellis, Alessandro;Comerford, James W.;Farmer, Thomas J.
• 通讯作者: Farmer, Thomas J.

Enzymatic synthesis of biobased polyesters utilizing aromatic diols as the rigid component

利用芳香族二醇作为刚性组分的生物基聚酯的酶法合成

• DOI: 10.1016/j.eurpolymj.2020.109680
• 发表时间: 2020
• 期刊: European Polymer Journal
• 影响因子: 6
• 作者: Pellis A