RADIOPAQUE RESTORATIVE AND PROSTHETIC DENTAL RESINS

不透射线的修复和修复牙科树脂

• 批准号: 3219903
• 负责人: NIKHIL K SARKAR
• 金额: $ 7.48万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-04-01 至 1988-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3219903
• 关键词: barium; biomaterial evaluation; chelating agents; composite resins; contrast media; dental materials; ligands; polymers; resin

Polymer resins used to fabricate dental and medical prostheses and dental restorations are generally radiolucent. Thus they are difficult to locate when accidently or purposely introduced into the body. Therefore accidents pose a hazard to patients and often lead to several medical emergencies and occasionally death, while in every case radiographic diagnosis is difficult. The seriousness of these problems is becoming ever more widely recognized. Currently, radiopacity is accomplished with metal or heavy-metal salts or galsses. These additives weaken the mechanical integrity because of the disparity between the low polarity of a hydrophobic resin and the high polarity or ionic and metallic additives. It is proposed that lthis problem can be solved by incorporating neutral ligands which are strongly complexed with a heavy-metal ion such as Ba, thus solubilizing a metal salt in the resin and forming a homogenous structure that retains mechanical strength and resists liquid penetration. The macrocyclic "crown" ethers and "glymes", and the polyphosphonate esters are proposed as the chelating species to be investigated for carrying radiopaque salts. The study will be a collaboration between polymer scientists at S.U.N.Y., Syracuse, and Biomaterials, radiology, microbiology and tissue-culture scientists at L.S.U. School of Dentistry in New Orleans. The chelating polymers will be synthesized at S.U.N.Y., under separate grant support, and supplied to L.S.U. where they will be formulated as prosthetic and restorative resins and evaluated for radiodensity, mechanical integrity, and probable biological safety. Radiodensity will be determined by film densitometry of x-ray images of trial specimens. Mechanical integrity will be determined using tests and standards specified by American Dental Society specifications for restorative and prosthetic resins. Probable safety will be assessed using the Ames mutagenicity test and tissue culture cytotoxicity techniques developed at LSU. Funding is being sought via two companion applications. Each have identical research plans but different institutional information and budget requests. The budget requestin in this application is designed to completely support that part of the proposed investigation that is to be performed by the L.S.U. group.

用于制造牙科和医疗假体以及牙科的聚合物树脂 修复体通常是射线可透过的。 因此很难找到它们 当意外或故意进入体内时。 因此发生事故 对患者构成危险并经常导致多种医疗紧急情况 偶尔会死亡，而在每种情况下，放射线诊断都可以 难的。 这些问题的严重性正变得越来越广泛 认可。 目前，射线不透性是通过金属或 重金属盐或玻璃。 这些添加剂削弱了机械性能 完整性，因为低极性之间的差异 疏水性树脂和高极性或离子和金属添加剂。 建议通过引入中立来解决这个问题 与重金属离子如Ba强络合的配体， 从而将金属盐溶解在树脂中并形成均匀的 保持机械强度并抵抗液体渗透的结构。 大环“冠”醚和“甘醇二甲醚”，以及聚膦酸酯 被提议作为要研究的螯合物种 不透射线的盐。 该研究将是聚合物之间的合作 纽约州立大学、雪城大学和生物材料、放射学、微生物学的科学家 和路易斯安那州立大学的组织培养科学家新牙科学院 奥尔良。 螯合聚合物将在纽约州立大学合成 单独的拨款支持，并提供给路易斯安那州立大学。他们将在哪里 配制为修复和修复树脂并进行评估 放射密度、机械完整性和可能的​​生物安全性。 放射密度将通过 X 射线图像的胶片光密度测定法确定 试验标本。 机械完整性将通过测试和确定 美国牙科协会规范指定的标准 修复和修复树脂。 将使用以下方法评估可能的安全性 艾姆斯致突变性试验和组织培养细胞毒性技术 在路易斯安那州立大学开发。 正在通过两个配套申请寻求资金。 各自有相同的研究计划但机构信息不同 和预算要求。 本申请中的预算要求是设计的 完全支持拟议调查的那部分 由 L.S.U. 执行团体。