CORROSION OF PD CONTAINING DENTAL ALLOYS

含 PD 牙科合金的腐蚀

• 批准号: 2458642
• 负责人: NIKHIL K SARKAR
• 金额: $ 16.16万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2458642
• 关键词: X ray spectrometry; alloys; biotransformation; chemical structure; cobalt; copper; corrosions; drug adverse effect; drug metabolism; electrochemistry; electrolytes; emission spectrometry; gallium; gold; hypersensitivity; metal dental material; oral facial restoration material; palladium; pharmacokinetics; saliva; scanning electron microscopy; silver; statistics /biometry; thermodynamics

The use of PdCu-based dental ceramic alloys has been linked to frequent incidence of allergy and hypersensitivity reactions. Whereas Pd has been suspected as the causative factor, the biological safety of other Pd- containing alloys has not been a matter of concern. The broad objective of this study is toe understand the reason why the PdCu-based alloy pose significantly greater risks to patients than some other alloys that also contain Pd. Corrosion is thought to play a major role in allergy and other alloys that also contain Pd. Corrosion is thought to play a major role in allergy and hypersensitivity. Therefore, a systematic study of the corrosion mechanism of selected Pd-containing alloys is proposed. The specific aims are (1) to study in vitro the corrosion behavior of 15 commercial and 9 experimental pd-containing alloys and their components in a synthetic saliva solution at 37 degrees Centrigrade, (2) to characterize the structural and compositional changes on the surface of these alloys due to corrosion, and (3) to determine the concentration of various metal ions released from these alloys during corrosion. The corrosion behavior will be studied by a number of electrochemical techniques and immersion tests. The electrochemical techniques will include (1) open-circuit-potential time measurement, (2) polarization corrosion test. Alloys subject to immersion and potentiostatic corrosion test will be examined and analyzed selectively by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and X-ray photoelectron spectroscopy (XPS), to define the corrosion- induced structural and compositional changes on various surfaces. Electrolytes from immersion tests will be analyzed by the inductively coupled plasma emission spectroscopy (ICP-ES) technique to determine the nature and concentration of various cations eluted during corrosion. The data will be interpreted thermodynamically to identify the electrochemical mechanism(s) of corrosion. Statistical analysis of the data will be performed to determine the effects of alloy composition and structure and their interaction effects on various corrosion parameters and to describe the difference among alloys on the basis of these parameters. These studies will contribute to a better understanding of the corrosion process of these alloys in vivo, and its possible contribution to adverse biological reactions.a

基于PDCU的牙科陶瓷合金的使用已与频繁相关 过敏和超敏反应的发生率。 而PD已经 涉嫌作为因果因素，是其他PD-的生物学安全 含有合金并不是一个问题。 广泛的目标 这项研究是脚趾了解基于PDCU的合金姿势的原因 患者对患者的风险明显高于其他合金的风险 包含PD。人们认为腐蚀在过敏和其他 还包含PD的合金。人们认为腐蚀在 过敏和超敏反应。 因此，对 提出了选定的含PD合金的腐蚀机制。 这 具体目的是（1）在体外研究15的腐蚀行为 商业和9种实验性PD合金及其成分 在37度中心的合成唾液溶液（2）以表征 这些合金表面的结构和组成变化 腐蚀，（3）确定各种金属离子的浓度 在腐蚀过程中从这些合金中释放出来。 腐蚀行为将 通过许多电化学技术和浸入测试进行研究。 电化学技术将包括（1）开路电位时间 测量，（2）极化腐蚀试验。 合金受到浸入 和电静脉腐蚀测试将被选择性检查和分析 通过扫描电子显微镜（SEM），能量分散性X射线光谱 （EDX）和X射线光电子光谱（XPS），以定义腐蚀 诱导各种表面的结构和组成变化。 浸入式测试的电解质将通过电感分析 耦合等离子体发射光谱（ICP-ES）技术以确定 在腐蚀过程中洗脱的各种阳离子的性质和浓度。 这 数据将在热力学上解释以识别电化学 腐蚀机制。 数据的统计分析将是 执行以确定合金组成和结构的影响以及 它们对各种腐蚀参数的相互作用影响，并描述 根据这些参数，合金之间的差异。 这些 研究将有助于更好地理解腐蚀过程 这些合金在体内及其对不利的可能贡献 生物反应