BIOLOGICAL MOLECULES IN THE CORROSION OF DENTAL ALLOYS

牙科合金腐蚀中的生物分子

• 批准号: 3220523
• 负责人: NIKHIL K SARKAR
• 金额: $ 13.02万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-01 至 1988-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3220523
• 关键词: X ray crystallography; alloys; aminoacid; biomaterial evaluation; carbonates; chemical reaction; chlorine; dental amalgam; dental material wear; electrochemistry; electrolytes; metal dental material; nuclear magnetic resonance spectroscopy; organic chemicals; phosphates; saliva

Corrosion is the primary mechanism for the tarnish, toxicity and degradation of dental alloys. The long-term objective of this study is to define the mechanism of corrosion in the oral environment. The specific aims are: (1) to determine in vitro the possible role of relevant biological molecules in the corrosion of selected dental alloys, and (2) to identify and characterize the electrochemical reaction(s) in the above corrosion process. The corrosion behavior of dental amalgams, casting golds, silver-palladium and nickel-chromium alloys will be studied by potentiostatic and potentiodynamic polarization measurements in electrolytes containing individual biological molecules, singly or in combination. Biological molecules to be examined, in addition to the major components of saliva (namely, chloride, phosphate, carbonate, etc.) will include amino acids, poly-alpha-amino acids, polypeptides and proteins. Corroded alloy surfaces will be examined and analyzed by SEM, energy dispersive X-ray spectroscopy, X-ray diffraction, NMR and FTIR in order to define precisely the alloy-electrolyte interaction. Electrolytes will be analyzed by atomic absorption spectroscopy to determine the nature and concentration of metal ions released during corrosion. These studies will, in the long run, bring about a better understanding of the corrosion process of dental alloys in vivo and its possible contribution to clinical problems associated with toxicity, tarnishing and mechanical degradation.

腐蚀是粉状，毒性和 牙齿合金的降解。 这项研究的长期目标是 定义口腔环境中腐蚀的机制。 具体 目的是：（1）在体外确定相关的可能作用 选定牙齿合金的腐蚀中的生物分子，（2）至 识别并表征上述电化学反应 腐蚀过程。 牙齿汞合金，铸造金，银钯的腐蚀行为 和镍铬合金将通过电位静态和 电解质中的电位动力学极化测量值 单个生物分子，单独或组合。 生物 除了唾液的主要成分外，要检查的分子 （即氯化物，磷酸盐，碳酸盐等）将包括氨基酸， 多α-氨基酸，多肽和蛋白质。 将通过SEM检查和分析腐蚀的合金表面 色散X射线光谱，X射线衍射，NMR和FTIR 准确定义合金 - 电解质相互作用。 电解质将是 通过原子吸收光谱法分析，以确定性质和 腐蚀过程中释放的金属离子的浓度。 从长远来看，这些研究将使人们更好地了解 体内牙齿合金的腐蚀过程及其可能 对与毒性，破坏和临床问题的贡献 机械降解。