Manufacture and applicator technologies for commercialisation of polymeric microneedle arrays

聚合物微针阵列商业化的制造和施用器技术

• 批准号: BB/K020234/1
• 负责人: Ryan Donnelly
• 金额: $ 90.4万
• 依托单位: Queen's University Belfast
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FK020234%2F1
• 关键词: Manufacture; applicator; technologies; commercialisation; polymeric

We have developed a novel type of transdermal patch with tiny needles on its surface that painlessly and without causing bleeding by-pass the skin's stratum corneum barrier. These needles either dissolve quickly, leaving tiny holes in the skin, which will let proteins and peptides enter the body, or swell, turning into a jelly-like material that keeps the holes open and allows continuous delivery. Our technology is unique and could potentially revolutionise delivery of medicines. Interestingly, we have also found that our swellable microneedles can extract fluid from the skin. This permits us to monitor the levels of drugs in a person's blood without actually taking blood samples, meaning that adverse events and complications arising from blood sampling could be prevented, to the benefit of patients Worldwide. In this project, we will focus on moving our microneedle production from laboratory scale to industrial scale and design and validation of a low-cost user friendly applicator.

我们开发了一种新型透皮贴剂，其表面带有细针，无痛且不会导致绕过皮肤角质层屏障的出血。这些针要么快速溶解，在皮肤上留下小孔，让蛋白质和肽进入体内，要么膨胀，变成果冻状材料，使孔保持打开状态并允许持续输送。我们的技术是独一无二的，有可能彻底改变药物的输送。有趣的是，我们还发现我们的可膨胀微针可以从皮肤中提取液体。这使我们能够在不实际采集血液样本的情况下监测人血液中的药物水平，这意味着可以预防血液采样引起的不良事件和并发症，从而造福全世界的患者。在这个项目中，我们将重点关注将微针生产从实验室规模转向工业规模，并设计和验证低成本用户友好的涂抹器。

项目成果

In vivo studies investigating biodistribution of nanoparticle-encapsulated rhodamine B delivered via dissolving microneedles.

体内研究调查通过溶解微针递送的纳米颗粒封装的罗丹明 B 的生物分布。

• DOI: http://dx.10.1016/j.jconrel.2017.04.022
• 发表时间: 2017
• 期刊: official journal of the Controlled Release Society
• 作者: Kennedy J

Vaccine delivery systems.

疫苗输送系统。

• DOI: http://dx.10.1080/21645515.2016.1259043
• 发表时间: 2017
• 期刊: Human vaccines & immunotherapeutics
• 影响因子: 4.8
• 作者: Donnelly RF

Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development

微针阵列作为透皮和皮内给药系统：材料科学、制造和商业开发

• DOI: 10.1016/j.mser.2016.03.001
• 发表时间: 2016-06-01
• 期刊: Materials Science & Engineering R-reports
• 影响因子: 31
• 作者: E. Larrañeta;Rebecca E. M. Lutton;A. Woolfson;R. Donnelly
• 通讯作者: R. Donnelly

A facile system to evaluate in vitro drug release from dissolving microneedle arrays.

一种评估溶解微针阵列体外药物释放的简便系统。

• DOI: http://dx.10.1016/j.ijpharm.2015.11.038
• 发表时间: 2016
• 期刊: International journal of pharmaceutics
• 作者: Larrañeta E

Patient safety and beyond: what should we expect from microneedle arrays in the transdermal delivery arena?

患者安全及其他：我们对透皮给药领域的微针阵列有何期望？

• DOI: 10.4155/tde.14.29
• 发表时间: 2014-08-04
• 期刊: Therapeutic delivery
• 影响因子: 4.2
• 作者: R. Donnelly;A. Woolfson
• 通讯作者: A. Woolfson