MODIFICATION OF TUMOR RESPONSE TO LOCAL IRRADIATION

改变肿瘤对局部辐射的反应

• 批准号: 3163743
• 负责人: JAY Steven LOEFFLER
• 金额: $ 35.2万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1975
• 资助国家: 美国
• 起止时间: 1975-10-01 至 1985-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3163743
• 关键词: Corynebacterium; breast neoplasms; cellular oncology; combination cancer therapy; fibrosarcoma; gamma radiation; histopathology; human subject; hyperbaric oxygen therapy; hypoxia; macrophage; metastasis; neoplasm /cancer immunotherapy; neoplasm /cancer radiation therapy; neoplasm /cancer remission /regression; neoplasm /cancer transplantation; neoplastic growth; radiation related neoplasm /cancer; radiation sensitivity; radiation therapy dosage; relative biological effectiveness; skin neoplasms

The observed marked improvement in efficacy of hyperbaric oxygen (O2 3ATA) by pentobarbital anesthesia to increase the response of C3H mammary carcinoma to irradiation will be evaluated using a series of spontaneous tumors (importance of histology, tumor size, anesthetic agent, depth of anesthesia, fractionation pattern, body temperature, blood perfusion of tumor, etc.) The potential of combining chemical sensitizers of hypoxic cells with hyperbaric oxygen to improve results of radiation therapy will be investigated in murine tumors; the two sensitizers will be combined at dose or PO2 levels which independently have comparable enhancement ratios. A "head on" comparison of the Therapeutic Gain Factors for photons plus O2 3ATA, photons plus misonidazole, and fast neutrons using a spectrum of spontaneous tumors of the C3Hf/Sed mouse is to be performed. The phenomenon of heat induced thermal tolerance will be studied to determine its time course, magnitude, dependence upon severity of the inducing heat treatment, time between the two exposures. Biological characterization of 9 spontaneous tumors is to be completed.

观察到高压氧 (O2 3ATA) 功效显着改善 戊巴比妥麻醉可增加 C3H 乳腺癌的反应 将使用一系列自发肿瘤来评估辐射（重要性 组织学、肿瘤大小、麻醉剂、麻醉深度、分割 模式、体温、肿瘤的血液灌注等）的潜力 将缺氧细胞的化学增敏剂与高压氧相结合 将在小鼠肿瘤中研究放射治疗的改善效果；这 两种敏化剂将在各自独立的剂量或 PO2 水平下组合 可比较的增强比率。 治疗收益的“正面”比较 光子加 O2 3ATA、光子加米索硝唑和快中子的因子 使用 C3Hf/Sed 小鼠的一系列自发性肿瘤进行研究。 将研究热诱导热耐受现象以确定 其时间进程、幅度、取决于感应热的严重程度 治疗、两次暴露之间的时间。 9 的生物学特性 自发性肿瘤即将完成。