PROTON RADIATION THERAPY RESEARCH

质子放射治疗研究

• 批准号: 2871655
• 负责人: JAY Steven LOEFFLER
• 金额: $ 412.86万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-31 至 2002-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2871655
• 关键词: neoplasm /cancer radiation therapy; proton beam

We will investigate whether the superior dose distributions (as compared to x-rays) of protons provides a therapeutic gain in the treatment of particular tumors. The sharp distal fall-off and lateral penumbra of proton dose distributions, and our ability to shape the distal edge (and also the proximal edge, during the course of the proposed research), of the proton stopping region, allow proton treatment volumes to conform more closely to the target volume than is possible with x-rays. As a consequence, the dose to the target can be increased and hence also the tumor control probability. Also, because there will be less normal tissue outside the target volume irradiated to a high dose, we anticipate that the frequency and severity of normal tissue damage will be reduced. In Project 1 we will design and carry out Phase I/II and III clinical trials in disease sites where we expect a significant clinical gain as a result of improved dose distributions achieved with protons. In Project 2 we will use the patient database acquired in Project 1 to analyze the dose response relationships for normal tissues and tumors. We will also conduct comparative treatment planning studies to inform us of possible new treatment sites and techniques. Project 3 provides the beam delivery, treatment planning, and treatment systems for the clinical studies conducted in Project 1. During the course of this program we will transfer the clinical research from the Harvard Cyclotron Laboratory to the Northeast Proton Therapy Center (NPTC). The new center, opening in mid- 1998, will have three treatment rooms, 2 with isocentric gantries, higher energy proton beams (up to 235 MeV), and state-of -the -art control systems for treatment, safety and accelerator control/ diagnostics. The NPTC will make it possible for us to provide proton treatments which are technically equivalent to advanced x-ray conformal therapy and therefore we can-test the theoretical superiority of proton dose distributions against the best x-ray treatments. Our very positive clinical results in skull base tumors and uveal melanomas, made possible by higher tumor doses without significant increases in treatment morbidity, give us confidence that we will have successes in other disease sites where tumor doses are now limited by sensitive normal structures. In addition, we have developed referral systems and clinical affiliate relationships which ensure that we will have adequate patients to conduct clinical trials in reasonable time frames. Most importantly, our team of experienced and dedicated researchers (physicians, clinical physicists, biostatisticians, and accelerator physicists) and excellent support staff, provide a breadth and depth of resources which will enable us to carry out the proposed research.

我们将研究是否优越的剂量分布（与 质子的 X 射线）在治疗中提供了治疗增益 特殊肿瘤。急剧的远端衰减和侧半影 质子剂量分布，以及我们塑造远端边缘的能力（和 也是近端边缘，在拟议的研究过程中）， 质子停止区域，使质子治疗体积更加一致 比 X 射线更接近目标体积。作为一个 结果，可以增加对目标的剂量，因此也可以增加 肿瘤控制概率。另外，因为正常组织会较少 在受到高剂量照射的目标体积之外，我们预计 正常组织损伤的频率和严重程度将会降低。在 项目1我们将设计并进行I/II期和III期临床试验 在我们期望由此获得显着临床收益的疾病部位 用质子实现的改进的剂量分布。在项目 2 中，我们将 使用项目1中获得的患者数据库来分析剂量 正常组织和肿瘤的反应关系。我们还将进行 比较治疗计划研究，让我们了解可能的新方法 治疗部位和技术。项目 3 提供光束传输， 临床研究的治疗计划和治疗系统 在项目 1 中进行。在该项目期间，我们将转移 哈佛回旋加速器实验室的临床研究 东北质子治疗中心 (NTPC)。新中心将于年中开业 1998年，将拥有三间治疗室，其中两间配有等中心龙门架，更高 能量质子束（高达 235 MeV）和最先进的控制 用于治疗、安全和加速器控制/诊断的系统。这 NPTC 将使我们能够提供质子治疗， 技术上等同于先进的 X 射线适形治疗，因此 我们可以测试质子剂量分布的理论优越性 反对最好的 X 射线治疗。我们非常积极的临床结果 颅底肿瘤和葡萄膜黑色素瘤，因较高的肿瘤剂量而成为可能 治疗发病率没有显着增加，给我们信心 我们将在肿瘤剂量较低的其他疾病部位取得成功 现在受到敏感正常结构的限制。此外，我们还开发了 转诊系统和临床附属关系确保我们 将有足够的患者在合理的时间内进行临床试验 帧。最重要的是，我们的团队经验丰富且敬业 研究人员（医生、临床物理学家、生物统计学家和 加速器物理学家）和优秀的支持人员，提供了广泛和 资源深度，使我们能够执行拟议的 研究。