PROTON RADIATION THERAPY RESEARCH

质子放射治疗研究

• 批准号: 3092949
• 负责人: JAY Steven LOEFFLER
• 金额: $ 204.14万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-08-01 至 1990-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3092949
• 关键词: acoustic nerve; carcinoma; cartilage neoplasm; chordoma; computed axial tomography; computer assisted medical decision making; computer assisted patient care; eye neoplasms; head /neck neoplasm; human subject; human therapy evaluation; lymph node neoplasm; melanoma; meningioma; mouth neoplasms; neoplasm /cancer radiation therapy; nerve sheath neoplasm; particle accelerators; patient monitoring device; prostate neoplasms; proton beam; radiation therapy dosage; radiodiagnosis; rectum neoplasms; relative biological effectiveness; tongue neoplasms; ultrasonography; acoustic nerve; carcinoma; cartilage neoplasm; chordoma; computed axial tomography; computer assisted medical decision making; computer assisted patient care; eye neoplasms; head /neck neoplasm; human subject; human therapy evaluation; lymph node neoplasm; melanoma; meningioma; mouth neoplasms; neoplasm /cancer radiation therapy; nerve sheath neoplasm; particle accelerators; patient monitoring device; prostate neoplasms; proton beam; radiation therapy dosage; radiodiagnosis; rectum neoplasms; relative biological effectiveness; tongue neoplasms; ultrasonography

Based on our extremely encouraging experience to date, we propose to pursue proton beam therapy for the treatment of cancer. We will continued randomized clinical trials of proton vs. x-ray therapy for stage T3-4 carcinoma of the prostate and for carcinoma of the floor of mouth and base of tongue. We will continue our non-randomized trials of proton beam therapy of chordomas and chondrosarcomas of the base of skull and cervical spine and of choroidal melanomas. We will determine whether the excellent local results seen to date with these sites is maintained. We plan two-dose randomized trials in selected patients in both these categories. We are planning new clinical trials in the treatment of paraaortic lymph node disease; meningiomas; superior sulcus tumors; acoustic neuromas; large choroidal melanomas; and anal and rectal tumors. We will take advantage of the unusual dose distributions obtained with proton beams to get clinical data concerning the tolerance of sensitive organs to partial volume irradiation and will correlate any observed treatment complications with the dose delivered to the sites involved. We will continue improvements in our capability to plan and deliver proton beam treatments with the goal of making possible the wider clinical dissemination of this treatment modality. One such project is to investigate the possibility of a "no touch" technique for the treatment of choroidal melanomas. The primary objective of the study is to evaluate whether the improvement in dose distributions achievable with proton beam therapy can be used to deliver an increased dose to the tumor with no greater and potentially less morbidity, and whether such an increased dose will lead to improvements in local control of cancer. If this program continues to demonstrate the advantages of protons which have been experienced to date, it will provide an important therapeutic option for several cancers which pose great difficulties for conventional treatment techniques.

根据我们迄今为止极富令人鼓舞的经验，我们建议追求 质子束治疗癌症。 我们将继续 质子与X射线治疗的随机临床试验，用于T3-4 前列腺癌和嘴巴的癌和底部癌 舌头。 我们将继续我们的非随机试验质子束 颅底和宫颈底部的丘多马斯和软骨肉瘤的疗法 脊柱和脉络膜黑色素瘤。 我们将确定优秀的 迄今为止看到这些站点的本地结果维持了。 我们计划 这两个类别中选定患者的两剂随机试验。 我们正在计划在治疗副淋巴的新临床试验 节点疾病；脑膜瘤；上沟肿瘤；声学神经瘤；大的 脉络膜黑色素瘤；以及肛门和直肠肿瘤。 我们将利用与 质子梁以获取有关敏感性耐受性的临床数据 器官部分辐射，并将与观察到的任何观察到 用剂量输送到所涉及的地点的治疗并发症。 我们 将继续提高我们计划和交付质子的能力 光束处理的目的是使更广泛的临床 传播这种治疗方式。 一个这样的项目是 调查“无触摸”技术的可能性 脉络膜黑色素瘤。 该研究的主要目的是评估是否有改进 在可以通过质子束疗法达到的剂量分布中，可以使用 给肿瘤增加剂量，没有更大的剂量 发病率以及这种增加的剂量是否会导致改善 局部控制癌症。 如果该程序继续证明 迄今为止经验丰富的质子的优势将提供 对于几种造成极大的癌症的重要治疗选择 常规治疗技术的困难。