PROTON RADIATION THERAPY RESEARCH

质子放射治疗研究

• 批准号: 6222799
• 负责人: JAY Steven LOEFFLER
• 金额: $ 212.55万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-31 至 2002-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6222799
• 关键词: neoplasm /cancer radiation therapy; proton beam

We will investigate whether the superior dose distributions (as compared to x-rays) of protons provides a therapeutic gain in the treatment of particular tumors. The sharp distal fall-off and lateral penumbra of proton dose distributions, and our ability to shape the distal edge (and also the proximal edge, during the course of the proposed research), of the proton stopping region, allow proton treatment volumes to conform more closely to the target volume than is possible with x-rays. As a consequence, the dose to the target can be increased and hence also the tumor control probability. Also, because there will be less normal tissue outside the target volume irradiated to a high dose, we anticipate that the frequency and severity of normal tissue damage will be reduced. In Project 1 we will design and carry out Phase I/II and III clinical trials in disease sites where we expect a significant clinical gain as a result of improved dose distributions achieved with protons. In Project 2 we will use the patient database acquired in Project 1 to analyze the dose response relationships for normal tissues and tumors. We will also conduct comparative treatment planning studies to inform us of possible new treatment sites and techniques. Project 3 provides the beam delivery, treatment planning, and treatment systems for the clinical studies conducted in Project 1. During the course of this program we will transfer the clinical research from the Harvard Cyclotron Laboratory to the Northeast Proton Therapy Center (NPTC). The new center, opening in mid- 1998, will have three treatment rooms, 2 with isocentric gantries, higher energy proton beams (up to 235 MeV), and state-of -the -art control systems for treatment, safety and accelerator control/ diagnostics. The NPTC will make it possible for us to provide proton treatments which are technically equivalent to advanced x-ray conformal therapy and therefore we can-test the theoretical superiority of proton dose distributions against the best x-ray treatments. Our very positive clinical results in skull base tumors and uveal melanomas, made possible by higher tumor doses without significant increases in treatment morbidity, give us confidence that we will have successes in other disease sites where tumor doses are now limited by sensitive normal structures. In addition, we have developed referral systems and clinical affiliate relationships which ensure that we will have adequate patients to conduct clinical trials in reasonable time frames. Most importantly, our team of experienced and dedicated researchers (physicians, clinical physicists, biostatisticians, and accelerator physicists) and excellent support staff, provide a breadth and depth of resources which will enable us to carry out the proposed research.

我们将研究上级剂量分布（比较 X射线）质子为治疗 特定的肿瘤。尖锐的远端掉落和外侧半月 质子剂量分布以及我们塑造远端边缘的能力（和 在拟议的研究过程中，也是近端边缘） 质子停止区域，允许质子处理量更大 与X射线相比，与目标体积接近目标体积。作为 结果，可以增加对目标的剂量，因此 肿瘤控制概率。另外，由于组织的正常组织较少 在目标量之外被照射为高剂量，我们预计 正常组织损伤的频率和严重程度将降低。在 项目1我们将设计和执行I/II和III期临床试验 在疾病部位，我们期望临床增长很大 通过质子实现的剂量分布的改善。在项目2中，我们将 使用项目1中获得的患者数据库分析剂量 正常组织和肿瘤的反应关系。我们还将进行 比较治疗计划研究，以告知我们可能的新 处理地点和技术。项目3提供了光束传递， 临床研究的治疗计划和治疗系统 在项目1中进行。在本计划的过程中，我们将转移 哈佛大学回合实验室的临床研究 东北质子治疗中心（NPTC）。新中心，在中间开业 1998年，将设有三个治疗室，2个具有同义为龙头的治疗室，较高 能量质子梁（最多235 meV）和最新 - 艺术控制 治疗，安全和加速器控制/诊断系统。这 NPTC将使我们有可能提供质子治疗 技术上等同于高级X射线形成型治疗，因此 我们可以测试质子剂量分布的理论优势 反对最好的X射线治疗。我们非常积极的临床结果 颅底肿瘤和紫​​veal黑色素瘤，由较高的肿瘤剂量使得 没有明显增加的治疗发病率，给我们信心 我们将在肿瘤剂量的其他疾病部位取得成功 现在受敏感正常结构的限制。此外，我们已经开发了 推荐系统和临床会员关系，确保我们 将有足够的患者在合理的时间内进行临床试验 帧。最重要的是，我们经验丰富的团队 研究人员（医师，临床物理学家，生物统计学家和 加速器物理学家）和优秀的支持人员，提供广度和 资源的深度将使我们能够执行拟议的 研究。