STRUCTURES OF ANTIBIOTICS AND RELATED COMPOUNDS

抗生素及相关化合物的结构

• 批准号: 3124204
• 负责人: KENNETH L RINEHART
• 金额: $ 24.54万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-05-01 至 1990-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3124204
• 关键词: Pseudomonas; Streptomyces; alkaloids; analytical chemistry; antibacterial agents; antibiotics; antifungal antibiotics; antineoplastic antibiotics; antiviral agents; chemical structure; gas chromatography; mass spectrometry; monoterpenes; oligopeptides; pigments; polyenes; stable isotope

Compounds with antiviral, antineoplastic, antifungal and antibacterial activities will be identified in marine species and their structures will be assigned. These include new components of the didemnin (antiviral, antineoplastic) and eudistomin (antiviral) complexes and an antineoplastic compound from Ecteinascidia turbinata, all from tunicates, as well as compounds from other tunicates and sponges. In addition, metabolites and quantitation of didemnin B will be studied in connection with its forthcoming clinical trials in cancer patients. Structures of a number of antibiotics will also be studied. These include the antifungal polyenes hamycin, aureofungin, and candimycin, as well as the non-polyenic antifungal macrolide desertomycin, the phospholipids quebemycin and 409 complex (antibacterial), the aromatic crisamicin (antineoplastic), and ficellomycin. Peptide antibiotics to be studied include saramycetin (antifungal), CC-1014B (cytotoxic), berninamycins A and B (antibacterial), antiamoebin, emerimicin, zervamicin, and alamethicin (all antibacterial and pore-forming). Bioactive compounds (antiviral) present in insects will also be identified and structural studies will be carried out on a Legionella pigment and a Pseudomonas growth factor.

抗病毒，抗肿瘤，抗真菌和抗菌的化合物 活动将在海洋物种中确定，其结构将 被分配。 其中包括didemnin的新组件（抗病毒， 抗塑性）和eudistomin（抗病毒）复合物以及抗肿瘤 来自turbinata的Ecteinascidia turbinata的化合物，全部来自中衣，以及 来自其他束缚剂和海绵的化合物。 另外，代谢物和 将研究dodemnin b的定量 癌症患者即将进行的临床试验。 还将研究多种抗生素的结构。 这些包括 抗真菌polyenes hamycin，Aureofungin和少女霉素，以及 非多生真正的抗真菌性大环内酯类脱霉素，磷脂 Quebemycin和409 Complex（抗菌），芳香族危机 （抗肿瘤）和纤毛霉素。 要研究的肽抗生素 包括萨拉米霉素（抗真菌），CC-1014b（细胞毒素），伯那霉素A和 b（抗菌），抗阿莫宾，艾美霉素，Zervamicin和alamethicin （所有抗菌和孔形成）。 昆虫中存在的生物活性化合物（抗病毒）也将被鉴定 结构研究将在军团菌色素和A上进行 假单胞菌生长因子。