LIPIDS AS MODULATORS OF GENE EXPRESSION

脂质作为基因表达的调节剂

• 批准号: 2884171
• 负责人: ROGER A DAVIS
• 金额: $ 1.5万
• 依托单位: SAN DIEGO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2884171
• 关键词: gene expression; lipids; meeting /conference /symposium; travel

DESCRIPTION (adapted from the applicant's abstract): It is known that specific lipids and their metabolites control the transcription of genes and mediate diverse aspects of intracellular signaling. Recent advances have defined the signaling molecule's transcription factors, auxiliary coactivators and corepressors and the mechanisms through which these factors act to regulate the expression of genes. These new insights may help to further our understanding of both normal physiological homeostatic control, i.e., cholesterol homeostasis mediated by feedback regulation through sterol-responsive element binding proteins (SREBPs) and the bases for certain pathophysiological states such as diabetes from insulin resistance and the role of peroxisomal proliferator activator receptor in this disease, also known as PPAR GAMMA. The opportunity to discover new therapeutics for the treatment of diseases caused by altered lipid metabolism, specifically hyperlipidemia, atherosclerosis, diabetes, obesity, and neurological disease has been realized by scientists working in research programs in academia and in industry. The function of this application is to provide support for the 1999 Kern Aspen Lipid Conference entitled "Lipids as Modulators of Gene Expression: Lipid Metabolism and Atherosclerosis." The goal of this is to present and discuss new findings in the area of transcriptional regulation of lipid metabolizing genes. The meeting is designed to allow for intensive didactic presentations and extensive interaction periods. Both directly following each presentation and during lunches and poster sessions the meeting will begin on Saturday afternoon and end mid-day Tuesday. A typical day's activities will include a four- to five-hour session with four speakers; each speaker will present for 30 minutes and then lead a discussion of 30 minutes. On Sunday a two-hour poster session is scheduled after lunch. Each poster session has 20 posters which will be presented by young investigators. One informal buffet dinner is held on Sunday evening to further allow for discussions between attendees. A brief summary of the meeting generally appears in the Journal of Lipid Research. The chairmen of the meeting are Roger Davis of San Diego State University and David Russell of the University of Texas SW Medical Center. Session I is transcriptional regulation of lipid metabolism; Session II is cellular signaling, gene expression and intracellular trafficking; Session III is the role of PPARgamma in lipid metabolism; and Session IV is gene expression in macrophages in the arterial wall. Session I will be moderated by Roger Davis, and speakers will be Joseph Goldstein, David Mangelsdorf, Bob Tjian, and H.S. Sul. The moderator is Session II will be David Russell, and speakers will be Phil Beachy, Thomas Sudhof, and Tom Innerarity. Session III will be moderated by Helen Hobbs; speakers will be Ron Evans, Chris Glass, Mike Milburn, and Helen Hobbs. Session IV will be moderated by Linda Curtiss and speakers will be Peter Edwards, Peter Libby, Steve Prescott, and Zena Werb. There will be an additional four oral sessions and two poster sessions.

描述（改编自申请人的摘要）：已知特定于 脂质及其代谢产物控制基因的转录并介导 细胞内信号的不同方面。最近的进步定义了 信号分子的转录因子，辅助共激活因子和 核心和这些因素调节的机制 基因的表达。这些新见解可能有助于进一步了解 两种正常的生理稳态控制，即胆固醇稳态 通过反馈调节通过固醇响应元件结合介导 蛋白质（SREBP）和某些病理生理状态的碱基，例如 胰岛素抵抗的糖尿病和过氧化物酶体增殖剂的作用 该疾病中的激活剂受体，也称为PPAR伽马。机会 发现新的治疗方法，以治疗因改变而引起的疾病 脂质代谢，特别是高脂血症，动脉粥样硬化，糖尿病， 肥胖和神经疾病已由从事的科学家实现 学术界和行业的研究计划。 该应用程序的功能是为1999年的克恩·阿斯彭（Kern Aspen）提供支持 脂质会议标题为“脂质作为基因表达的调节剂：脂质 代谢和动脉粥样硬化。”目的是提出和讨论新的 脂质代谢基因转录调节领域的发现。 会议旨在允许进行密集的教学演示和 广泛的互动期。两者都直接遵循每个演示文稿，以及 在午餐和海报会议期间，会议将在星期六下午开始 并结束星期二的中午。典型的一天的活动将包括四到 与四名演讲者进行了五小时的会议；每个发言人将出席30分钟 然后进行30分钟的讨论。周日举行了两个小时的海报会议 午餐后安排。每个海报会议都有20个海报 由年轻调查员提出。周日举行一顿非正式的自助餐晚餐 晚上，进一步允许与会者之间的讨论。简要摘要 会议通常出现在脂质研究杂志上。主席 会议是圣地亚哥州立大学的罗杰·戴维斯（Roger Davis）和 德克萨斯大学SW医学中心。 IS I是脂质代谢的转录调节；会议第二会 细胞信号传导，基因表达和细胞内运输；会议III 是ppargamma在脂质代谢中的作用；和会议IV是基因表达 在动脉壁中的巨噬细胞中。 会议我将由罗杰·戴维斯（Roger Davis）主持，演讲者将是约瑟夫 Goldstein，David Mangelsdorf，Bob Tjian和H.S. sul。主持人是会话 II将是David Russell，演讲者将是Phil Beachy，Thomas Sudhof，以及 汤姆内在。第三会议将由海伦·霍布斯（Helen Hobbs）主持；演讲者会 罗恩·埃文斯，克里斯·格拉斯，迈克·米尔本和海伦·霍布斯。会议IV将是 由琳达·柯蒂斯（Linda Curtiss）和演讲者主持的彼得·爱德华兹（Peter Edwards），彼得·利比（Peter Libby）， 史蒂夫·普雷斯科特（Steve Prescott）和Zena Werb。还会有四个口头会议 和两个海报会议。