Brain Uptake and Utilization of Fatty Acids and Lipids

大脑对脂肪酸和脂质的摄取和利用

• 批准号: 6838021
• 负责人: Paul A. WATKINS
• 金额: $ 2万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6838021
• 关键词: blood lipoprotein; brain metabolism; fatty acids; lipid transport; lipids; meeting /conference /symposium; nervous system disorder; travel

DESCRIPTION (provided by applicant) A scientific meeting "Brain Uptake and Utilization of Fatty Acids, Lipids and Lipoproteins: Applications to Neurological Disorders (An International Workshop)" to be held at the Bethesda Holiday Inn Select, October 7-9, 2004, is proposed. The objectives are to examine the current state of knowledge of how lipids, primarily fatty acids (FA), and lipoproteins are taken up and utilized by the brain, to provide a forum for ample interchange of ideas and information between participants of diverse backgrounds, and to identify areas for future research. Workshop topics will include: FA and lipid transport across membranes in the brain; brain metabolism of polyunsaturated FA (PUFA) with emphasis on the physiological functions of eicosenoids; functions of docosahexaenoic acid (DHA) in neurons and neuronal membranes and the roles of DHA and other PUFA in neurological diseases; and roles of lipids and lipoproteins in peroxisomal disorders and in Alzheimer's disease. Continuing disagreement and contreversy over mechanism(s) by which all cells transport FA across the plasma membrane precludes a clear understanding of how FA enter the brain, where this process is further complicated by the presence of the blood-brain barrier. It is vital to clarify brain FA transport and utilization mechanisms, both understanding normal brain development and function and for the diagnosis and therapy of human neurodegenerative diseases, some of which may be amenable to non-invasive, dietary therapy. This conference is timely because a) there is tremendous impetus for brain research with the recent establishment of several new large centers, and b) advances in biochemistry, biophysics, genetics, neuroimaging, and nutrition have led to specialization and an information explosion. We propose that new insights can be consolidated and enhanced by bringing together investigators and clinicians from this wide range of disciplines which will catalyze application of new information to the diagnosis and treatment of human disease. The proposed format of the conference is unique in its emphasis on open discussions of the issues, their implications and contreversies rather than on didactic presentation. Expected outcomes include emergence of new hypotheses and establishment of new collaborations that integrate different disciplines. Our previous conference in March 2000, with similar objectives, was highly successful in the eyes of participants, attendees, and sponsors. The entire proceedings, including talks, posters, discussions, and recommendations for future research were published in a double issue of J. Mol. Neurosci., which has committed to publish the proceedings of the proposed meeting.

说明（由申请人提供） 将于 2004 年 10 月 7 日至 9 日在 Bethesda Holiday Inn Select 举行的科学会议“脂肪酸、脂质和脂蛋白的大脑摄取和利用：神经系统疾病的应用（国际研讨会）”建议的。目的是检查大脑如何吸收和利用脂质（主要是脂肪酸 (FA) 和脂蛋白）的知识现状，为不同背景的参与者之间充分交流想法和信息提供论坛，以及以确定未来研究的领域。研讨会主题包括： FA 和大脑中跨膜脂质运输；多不饱和脂肪酸（PUFA）的脑代谢，重点关注类二十烯酸的生理功能；二十二碳六烯酸 (DHA) 在神经元和神经元膜中的功能以及 DHA 和其他 PUFA 在神经系统疾病中的作用；以及脂质和脂蛋白在过氧化物酶体疾病和阿尔茨海默病中的作用。关于所有细胞跨质膜转运 FA 的机制持续存在分歧和争议，阻碍了对 FA 如何进入大脑的清晰理解，而血脑屏障的存在使这一过程变得更加复杂。阐明大脑 FA 的运输和利用机制至关重要，无论是了解正常的大脑发育和功能，还是人类神经退行性疾病的诊断和治疗，其中一些疾病可能适合非侵入性饮食疗法。这次会议是及时的，因为：a）最近建立了几个新的大型中心，对大脑研究产生了巨大的推动力；b）生物化学、生物物理学、遗传学、神经影像学和营养学的进步导致了专业化和信息爆炸。我们建议，通过将来自广泛学科的研究人员和临床医生聚集在一起，可以巩固和增强新的见解，这将促进新信息在人类疾病诊断和治疗中的应用。拟议的会议形式的独特之处在于它强调 对问题及其影响和争议进行公开讨论，而不是说教式的陈述。预期成果包括新假设的出现和整合不同学科的新合作的建立。我们于 2000 年 3 月举行的上一次会议有着类似的目标，在与会者、出席者和赞助商看来非常成功。整个会议记录，包括演讲、海报、讨论和对未来研究的建议，均发表在《J. Mol》双刊上。 Neurosci.，已承诺公布拟议会议的记录。