The Neural Bases of Decision-Making

决策的神经基础

• 批准号: DP150104878
• 负责人: Prof Bernard Balleine
• 金额: $ 74.64万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150104878
• 关键词: Neural; Bases; Decision; Making

The smooth integration of cognitive and emotional processes is necessary for everyday decisions. Dysfunction in this integrative capacity accompanies dementia, neurodegenerative conditions and major psychiatric disorders. This project seeks to understand the neural bases of this integration in normal decision-making using cutting edge behavioural, cellular, molecular and genetic tools to map the neural system, circuit and cellular processes controlling the selection, evaluation and choice of goal-directed actions. Such actions can, with continued practice, transition into relatively inflexible habits. Thus, this project aims to investigate the neural processes that mediate this transition and how actions and habits interact in normal decision-making.

认知和情感过程的顺利整合对于日常决策是必要的。这种整合能力的功能障碍伴随着痴呆、神经退行性疾病和主要精神疾病。该项目旨在利用尖端的行为、细胞、分子和遗传工具来了解正常决策中这种整合的神经基础，以绘制控制目标导向行动的选择、评估和选择的神经系统、回路和细胞过程。通过不断练习，这些行为可以转变为相对僵化的习惯。因此，该项目旨在研究介导这种转变的神经过程以及行为和习惯在正常决策中如何相互作用。