What is the role of striatal dopamine in value-based decision-making?

纹状体多巴胺在基于价值的决策中发挥什么作用？

• 批准号: DP240103246
• 负责人: Prof Bernard Balleine
• 金额: $ 103.4万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2028-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240103246
• 关键词: What; role; striatal; dopamine; value

The aim of this project is to understand the role of dopamine in the brain circuits controlling goal-directed action. Its significance lies in our use of newly developed tools to measure dopamine release and cellular activity concurrently to assess the causal role of this interaction in choice and decision-making. The expected outcome of this project is to provide a comprehensive understanding of the role of dopamine release in striatal cellular activity and in the psychological processes mediating goal-directed decision-making. This outcome will have the benefit of filling a gap in our knowledge of the brain processes mediating decision-making, a fundamental capacity that contributes to our physical and psychological wellbeing (wellness).

该项目的目的是了解多巴胺在控制目标导向行动的大脑回路中的作用。其意义在于我们使用新开发的工具来同时测量多巴胺释放和细胞活动，以评估这种相互作用在选择和决策中的因果作用。该项目的预期成果是全面了解多巴胺释放在纹状体细胞活动和介导目标导向决策的心理过程中的作用。这一结果将有利于填补我们对大脑调节决策过程的知识空白，这是一种有助于我们身心健康的基本能力。