OPTICAL AND ELECTRICAL MEASURES OF BRAIN FUNCTION

脑功能的光学和电学测量

• 批准号: 6011740
• 负责人: Gabriele Gratton
• 金额: $ 43.24万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6011740
• 关键词: bioimaging /biomedical imaging; blood flow measurement; brain circulation; brain electrical activity; brain imaging /visualization /scanning; brain mapping; clinical research; diagnosis design /evaluation; electroencephalography; evoked potentials; functional magnetic resonance imaging; human subject; neurophysiology; noninvasive diagnosis; optics; technology /technique development

DESCRIPTION (Adapted from Applicant's Abstract): This is the first competing continuation of a proposal that was aimed at the development of a new non-invasive brain imaging method, the event-related optical signal (EROS). The purposes of this continuation are (a) to further extend the development of this method and knowledge about its spatial and temporal resolution in a systematic and parametric fashion, and (b) to compare and integrate it with other existing electrical and hemodynamic brain imaging techniques (the event-related brain potential, or ERP, and functional Magnetic Resonance Imaging, or fMRI). Functional brain imaging methods are becoming a central tool in the study of brain function, and have a number of potential applications in neurology, psychiatry, aging research, etc. However, presently available techniques emphasize either spatial or temporal resolution. This separate emphasis on temporal or spatial information does not always provide an accurate depiction of the rapid interactions between brain areas that are likely to underlie most complex brain functions. Work conducted during the initial funding period has established that EROS possesses a unique combination of spatial and temporal specificity. In addition, EROS can be interfaced with other techniques emphasizing spatial (such as fMRI) or temporal resolution (such as the ERP) to increase further the quality of the spatial and temporal information available to the investigator. The specific aims of this proposal are related to the practical development of this imaging approach as a tool in the study of brain function. They include answers to the following questions: (A) How specific and accurate are the estimates of the time course of activity in a particular cortical area obtained with EROS? (B) What are the minimum temporal and spatial separations between the activities in different areas that are discriminable with EROS? (C) Can EROS be used to detect patterns of correlation and coherence between the activity in different areas?

描述（改编自申请人的摘要）：这是第一个竞争性的 继续一项旨在开发新的 非侵入性脑成像方法，事件相关光信号（EROS）。这 这一延续的目的是 (a) 进一步扩展这一项目的发展 系统地了解其空间和时间分辨率的方法和知识 和参数化时尚，以及（b）将其与其他现有的进行比较和整合 电和血流动力学脑成像技术（事件相关脑 电位（ERP）和功能磁共振成像（fMRI）。 功能性脑成像方法正在成为研究的核心工具 大脑功能，并在神经学中有许多潜在的应用， 精神病学、衰老研究等。然而，目前可用的技术 强调空间或时间分辨率。这个单独强调 时间或空间信息并不总是提供准确的描述 大脑区域之间的快速相互作用可能是大多数 复杂的大脑功能。初始资助期间开展的工作 确定 EROS 拥有独特的空间和时间组合 特异性。此外，EROS 可以与其他技术连接 强调空间分辨率（例如 fMRI）或时间分辨率（例如 ERP） 进一步提高可用空间和时间信息的质量 给调查员。该提案的具体目标涉及 这种成像方法作为大脑研究工具的实际发展 功能。它们包括对以下问题的回答： (A) 有多具体和 准确的是对特定活动的时间过程的估计 用 EROS 获得的皮质面积？ (B) 最小时间和空间是多少 可区分的不同领域的活动之间的分离 与爱欲？ (C) EROS 可以用来检测相关性和一致性的模式吗 不同领域的活动之间？