OPTICAL AND ELECTRICAL MEASURES OF BRAIN FUNCTION

脑功能的光学和电学测量

基本信息

批准号：
6652461
负责人：
Gabriele Gratton
金额：
$ 37.27万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
起止时间：
1996-09-30 至 2005-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6652461
关键词：
bioimaging /biomedical imaging blood flow measurement brain circulation brain electrical activity brain imaging /visualization /scanning brain mapping clinical research diagnosis design /evaluation electroencephalography evoked potentials functional magnetic resonance imaging human subject neurophysiology noninvasive diagnosis optics technology /technique development

项目摘要

DESCRIPTION (Adapted from Applicant's Abstract): This is the first competing continuation of a proposal that was aimed at the development of a new non-invasive brain imaging method, the event-related optical signal (EROS). The purposes of this continuation are (a) to further extend the development of this method and knowledge about its spatial and temporal resolution in a systematic and parametric fashion, and (b) to compare and integrate it with other existing electrical and hemodynamic brain imaging techniques (the event-related brain potential, or ERP, and functional Magnetic Resonance Imaging, or fMRI). Functional brain imaging methods are becoming a central tool in the study of brain function, and have a number of potential applications in neurology, psychiatry, aging research, etc. However, presently available techniques emphasize either spatial or temporal resolution. This separate emphasis on temporal or spatial information does not always provide an accurate depiction of the rapid interactions between brain areas that are likely to underlie most complex brain functions. Work conducted during the initial funding period has established that EROS possesses a unique combination of spatial and temporal specificity. In addition, EROS can be interfaced with other techniques emphasizing spatial (such as fMRI) or temporal resolution (such as the ERP) to increase further the quality of the spatial and temporal information available to the investigator. The specific aims of this proposal are related to the practical development of this imaging approach as a tool in the study of brain function. They include answers to the following questions: (A) How specific and accurate are the estimates of the time course of activity in a particular cortical area obtained with EROS? (B) What are the minimum temporal and spatial separations between the activities in different areas that are discriminable with EROS? (C) Can EROS be used to detect patterns of correlation and coherence between the activity in different areas?

描述（改编自申请人的摘要）：这是第一个竞争延续旨在开发新的提案非侵入性脑成像法，事件相关的光学信号（ERO）。这这种延续的目的是（a）进一步扩展了这一点的发展在系统的方法和知识中，有关其空间和时间分辨率和参数方式，以及（b）将其与其他现有的电和血流动力学大脑成像技术（与事件相关的大脑电势或ERP以及功能性磁共振成像或fMRI）。功能性脑成像方法正在成为研究的中心工具大脑功能，并具有许多潜在的神经学应用程序，但是，精神病学，衰老研究等目前可用的技术强调空间或时间分辨率。这种不同的强调时间或空间信息并不总是提供准确的描述大脑区域之间可能是大多数基础的大脑区域之间的快速相互作用复杂的大脑功能。最初资金期间进行的工作已有确定爱神具有空间和时间的独特组合特异性。此外，ERO可以与其他技术连接强调空间（例如fMRI）或时间分辨率（例如ERP）进一步提高可用时空信息的质量致调查员。该提案的具体目的与这种成像方法作为大脑研究的工具的实际开发功能。它们包括以下问题的答案：（a）准确是特定活动时间过程的估计值用爱神获得的皮质区域？（b）最小时间和空间是什么在不同领域的活动之间的分离与爱神？（c）可以将爱神用于检测相关模式和相干性在不同地区的活动之间？