COOPERATIVE INTERAREAL PROCESSING OF VISUAL CONTOURS

视觉轮廓的协作域间处理

• 批准号: 2882926
• 负责人: ANNA W. ROE
• 金额: $ 23.08万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2882926
• 关键词: Aotus; Macaca; behavioral /social science research tag; cats; cell cell interaction; electrophysiology; histology; microelectrodes; neural information processing; neuroanatomy; optics; synapses; visual cortex; visual perception; visual stimulus

The mammalian cerebral cortex is characterized by multiple cortical areas, each with a separate representation of the sensory world. However, the role of multiple representation in sensory information processing is unknown. As a prelude to understanding how multiple cortical areas cooperatively process visual percepts, this proposal aims to study contour representation within V2 (the second visual cortical area) and its interaction with contour representation in V1 (primary visual cortex). Orientation selective cells in V1 are well known to be responsive to luminance contrast edges. However, many visual contours are not defined by luminance contrast but rather by higher order features (such as occluded contours or texture pattern borders). Area V2, the second major stage of visual cortical processing, is characterized by cells which prefer such higher order features. This proposal will explore the idea that different cortical areas process different levels or abstractions of visual contours and examine how these separate representations interact. Specifically, the organization and interactions between cells responsive to real contours and those responsive to higher order contours will be examined. These circuitries will be examined for each of the color, form, and disparity domains which together comprise V2. The stated goals will be achieved by using a combination of optical imaging, electrophysiological, and anatomical methods. V1-V2 interactions will be studied with both cross correlation methods and optical imaging of V1-V2 activation in response to "spot" stimuli (a functional tract tracing method); these will be compared with connectivity patterns revealed anatomically. In addition, differences in contour saliency due to geometrical or featural characteristics will he related to stimulus- related changes in interaction patterns. By elucidating the neural circuitry underlying contour perception in V1 and V2, this research will offer insight into whether different cortical areas mutually reinforce the same information (i.e. interactions between similarly oriented real and higher order contour cells) or whether a more hierarchical relationship exists in which the outputs of one area are used to construct a quite different representation in another area (interactions between differently oriented real and higher order contour cells). Alternatively, different strategies could be used under different contexts, a possibility that would be supported by stimulus-related changes in connectivity or activation of different populations of contour cells in V2.

哺乳动物脑皮质的特征是多层皮质 区域，每个区域都有独立的感官世界的代表。然而， 多个表示在感官信息处理中的作用是 未知。作为了解多个皮质区域的前奏 该提案合作处理视觉感知，旨在研究 V2（第二视觉皮质区域）内的轮廓表示和 它与V1中轮廓表示的相互作用（主要视觉 皮质）。 V1中的方向选择性细胞众所周知 响应亮度对比边缘。但是，许多视觉轮廓是 不是由亮度对比定义，而是由高阶功能定义 （例如遮挡的轮廓或纹理图案边框）。区域V2， 视觉皮质处理的第二个主要阶段的特征是 喜欢这样高阶特征的单元。该建议将探索 不同的皮质区域处理不同级别或 视觉轮廓的抽象，并检查这些如何分开 表示相互作用。具体而言，组织和互动 在响应真实轮廓的细胞与对较高响应的细胞之间 将检查订单轮廓。这些电路将进行检查 共同组成的每个颜色，形式和差异域 v2。既定目标将通过使用光学的组合来实现 成像，电生理和解剖方法。 V1-V2相互作用 将使用跨相关方法和光学成像研究 响应“斑点”刺激的V1-V2激活 跟踪方法）；这些将与连通性模式进行比较 解剖学揭示。另外，应得的轮廓显着性差异 对于几何或特征特征，他将与刺激有关 相互作用模式的相关变化。 通过阐明V1中的神经电路感知的神经电路 和v2，这项研究将提供有关是否不同皮质的洞察力 区域相互加强相同的信息（即 类似地定向的真实和高阶轮廓单元格）或是否更多 存在分层关系，其中一个区域的产出为 用于在另一个区域构建完全不同的表示 （不同面向的真实和高阶轮廓之间的相互作用 细胞）。另外，可以在不同的情况下使用不同的策略 上下文，这种可能性将由刺激相关的可能性 连通性的变化或不同种群轮廓的激活 V2中的细胞。