DEVELOPMENT OF BORDERLINE PERSONALITY DISORDER FEATURES

边缘性人格障碍特征的发展

• 批准号: 2890619
• 负责人: Timothy J Trull
• 金额: $ 19.45万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2890619
• 关键词: adolescence (12-20); borderline personality disorder; child abuse; clinical research; disease /disorder etiology; gender difference; human subject; mental health epidemiology; parent offspring interaction; personality; university student; young adult human (21-34)

Borderline personality disorder (BPD) is a sever personality disorder that develops in early adulthood, and is characterized by a lack of control of anger, intense and frequent mood changes, impulsive acts, disturbed interpersonal relationships, and life-threatening behaviors. BPD is relatively prevalent in both clinical and nonclinical populations. Despite the prevalence of this condition, we know very little about how BPD features develop. Although a number of etiological factors have been proposed, studies exploring the etiological relevance of these factors suffer from a number of methodological limitations including: assessing subjects only after they have developed BPD, failing to assess gender effects, and employing cross-sectional designs. This application proposes a two-year prospective multi-cohort study of 500 18 year-old subjects that manifest varying degrees of BPD features; both genders will be equally represented. All subjects will be incoming freshman at the University of Missouri-Columbia, and subjects will complete a number of inventories and interviews at study intake (Time 1) and two-year follow-up (Time 2) that target the following constructs: BPD and other personality disorder features; parental psychopathology; and abuse experiences in childhood. The proposed study has five major aims: (1) to assess the correspondence between alternative measures of BPD features (self-report and interview); (2) to assess the relationship between personality traits and BPD features and determine whether the relations remain significant after partialling out variance in BPD scores accounted for by gender, parental psychopathology childhood physical and sexual abuse, and Axis l pathology; (3) to assess the two-year stability of scores on BPD measures; (4) To evaluate several models of how BPD features develop over time that include personality trail childhood abuse experiences, and parental psychopathology as moderators or mediators; and (5) to assess the relationship between Time 1 BPD symptom scores and negative outcome across a number of domains functioning, and to evaluate the potential moderating influence of personality traits, childhood abuse, and parental psychopathology on the relationship between Time 1 BPD scores and outcome two years later. By addressing these five aims, factors influencing future BPD pathology will be identified, more comprehensive etiological mode for BPD will be empirically evaluated, the level of dysfunction exhibited by syndromal and subsyndromal subjects will be assessed, and the predictive validity of BPD scores will be determined.

边缘人格障碍（BPD）是一种严重的人格障碍 成年初期发展，其特征是缺乏对 愤怒，激烈和频繁的情绪变化，冲动行为，干扰 人际关系和威胁生命的行为。 BPD是 在临床和非临床人群中相对普遍。尽管 这种情况的流行，我们对BPD的了解一无所知 发展功能。尽管许多病因已 提出的研究探讨了这些因素的病因相关性 受到许多方法上的局限性，包括：评估 仅在受试者发展BPD之后，无法评估性别 效果，并采用横截面设计。此申请提出 一项为期两年的前瞻性多核研究研究，对500名18岁的受试者 明显不同程度的BPD特征；两性性别将同样 代表。所有学科将在大学的新生 密苏里州哥伦比亚，受试者将完成许多库存， 研究摄入量（时间1）和两年随访（时间2）的访谈 针对以下结构：BPD和其他人格障碍 特征;父母心理病理学；和童年时期的虐待经历。 拟议的研究具有五个主要目的：（1）评估对应关系 在BPD功能的替代度量（自我报告和访谈）之间； （2）评估人格特质与BPD之间的关系 特征并确定关系是否在 性别占BPD分数的偏差差异 精神病理学儿童时期的身体和性虐待以及轴L病理学； （3）评估BPD措施分数的两年稳定性； （4）至 评估BPD功能如何随时间发展的几种模型，包括 个性落后儿童虐待经历和父母 心理病理学作为主持人或介体； （5）评估 时间1 BPD症状分数与整个负面结果之间的关系 许多域运行，并评估潜在的调节 人格特质，童年虐待和父母的影响 关于时间1 BPD分数与结果之间关系的心理病理学 两年后。通过解决这五个目标，影响未来的因素 将确定BPD病理学，更全面的病因模式 BPD将经过经验评估，由 将评估综合征和亚综合征学主体，并进行预测 将确定BPD分数的有效性。