DEVELOPMENT OF BORDERLINE PERSONALITY DISORDER FEATURES

边缘性人格障碍特征的发展

• 批准号: 2675229
• 负责人: Timothy J Trull
• 金额: $ 20.68万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2675229
• 关键词: adolescence (12-20); borderline personality disorder; child abuse; clinical research; disease /disorder etiology; gender difference; human subject; mental health epidemiology; parent offspring interaction; personality; university student; young adult human (21-34)

Borderline personality disorder (BPD) is a sever personality disorder that develops in early adulthood, and is characterized by a lack of control of anger, intense and frequent mood changes, impulsive acts, disturbed interpersonal relationships, and life-threatening behaviors. BPD is relatively prevalent in both clinical and nonclinical populations. Despite the prevalence of this condition, we know very little about how BPD features develop. Although a number of etiological factors have been proposed, studies exploring the etiological relevance of these factors suffer from a number of methodological limitations including: assessing subjects only after they have developed BPD, failing to assess gender effects, and employing cross-sectional designs. This application proposes a two-year prospective multi-cohort study of 500 18 year-old subjects that manifest varying degrees of BPD features; both genders will be equally represented. All subjects will be incoming freshman at the University of Missouri-Columbia, and subjects will complete a number of inventories and interviews at study intake (Time 1) and two-year follow-up (Time 2) that target the following constructs: BPD and other personality disorder features; parental psychopathology; and abuse experiences in childhood. The proposed study has five major aims: (1) to assess the correspondence between alternative measures of BPD features (self-report and interview); (2) to assess the relationship between personality traits and BPD features and determine whether the relations remain significant after partialling out variance in BPD scores accounted for by gender, parental psychopathology childhood physical and sexual abuse, and Axis l pathology; (3) to assess the two-year stability of scores on BPD measures; (4) To evaluate several models of how BPD features develop over time that include personality trail childhood abuse experiences, and parental psychopathology as moderators or mediators; and (5) to assess the relationship between Time 1 BPD symptom scores and negative outcome across a number of domains functioning, and to evaluate the potential moderating influence of personality traits, childhood abuse, and parental psychopathology on the relationship between Time 1 BPD scores and outcome two years later. By addressing these five aims, factors influencing future BPD pathology will be identified, more comprehensive etiological mode for BPD will be empirically evaluated, the level of dysfunction exhibited by syndromal and subsyndromal subjects will be assessed, and the predictive validity of BPD scores will be determined.

边缘性人格障碍（BPD）是一种严重的人格障碍， 发生在成年早期，其特点是缺乏对事物的控制。 愤怒、强烈而频繁的情绪变化、冲动行为、不安 人际关系和危及生命的行为。边缘性人格障碍是 在临床和非临床人群中都相对普遍。尽管 这种情况的普遍性，我们对 BPD 是如何发生的知之甚少 特征发展。尽管许多病因已被证实 提出，研究探索这些因素的病因学相关性 受到许多方法论的限制，包括： 受试者仅在患有 BPD 后才评估性别 效果，并采用横截面设计。本申请提出 一项针对 500 名 18 岁受试者的为期两年的前瞻性多队列研究 表现出不同程度的BPD特征；男女将是平等的 代表。所有科目均为大学新生 密苏里-哥伦比亚，受试者将完成一些清单和 研究入学（时间 1）和两年随访（时间 2）时的访谈 针对以下结构： BPD 和其他人格障碍 特征;父母精神病理学；以及童年时期的虐待经历。 拟议的研究有五个主要目的：（1）评估对应性 BPD 特征的替代测量方法（自我报告和访谈）； (2)评估人格特质与BPD的关系 特征并确定关系在之后是否仍然显着 部分消除 BPD 分数因性别、父母而造成的差异 精神病理学、儿童身体虐待和性虐待，以及轴 l 病理学； (3) 评估 BPD 测量分数的两年稳定性； (4) 至 评估 BPD 功能如何随时间发展的几种模型，包括 人格轨迹童年虐待经历，以及父母 精神病理学作为调节者或调解者； (5) 评估 时间 1 BPD 症状评分与负面结果之间的关系 许多领域发挥作用，并评估潜在的调节作用 人格特质、童年虐待和父母的影响 时间 1 BPD 评分与结果之间关系的精神病理学 两年后。通过解决这五个目标，影响未来的因素 BPD病理将被识别，更全面的病因模式 BPD 将根据经验进行评估，所表现出的功能障碍水平 将评估综合症和亚综合症受试者，并预测 BPD 分数的有效性将被确定。