Borderline Adolescent Family Therapy Trial

边缘青少年家庭治疗试验

• 批准号: 7113623
• 负责人: DANIEL A. SANTISTEBAN
• 金额: $ 49.06万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-16 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7113623
• 关键词: adolescence (12-20); behavior therapy; behavioral /social science research tag; borderline personality disorder; child mental disorders; clinical research; counseling; emotional adjustment; family structure /dynamics; family therapy; high risk behavior /lifestyle; human subject; longitudinal human study; mathematical model; medical rehabilitation related tag; psychosocial rehabilitation; self destructive behavior; substance abuse related behavior; substance abuse related disorder

DESCRIPTION (provided by applicant): The proposed Stage I-B study focuses on adolescents who meet criteria for both Borderline Personality Disorder (BPD) and Substance Abuse Disorder. These adolescents display a pattern of self-destructive behaviors (suicide attempts, self-mutilization, violent reactions) that intensify and exacerbate their drug abuse, and severely disrupt treatment and family relations. This constellation of symptoms and their severity require specialized interventions. A previous NIDA funded Stage I study led to the development of the Integrative Borderline Adolescent Family Therapy (I-BAFT) model that integrated 1) Linehan's work on skills training specifically for Borderline adults with 2) family treatment based on Structural Family Therapy shown efficacious with substance abusing adolescents and 3) individual level interventions adapted for this specific subtype of drug abuser. This application proposes to conduct a "Stage I-B study of behavioral and psychosocial therapies for substance abuse disorder" testing the newly developed I-BAFT in a small randomized trial and providing a more substantial test of its efficacy, to obtain the necessary indicators needed for a Stage II trial. In addition to focusing on drug and BPD outcomes, the study will also obtain preliminary indicators of impact on hypothesized mediators (e .g. family functioning and emotion regulation). We will recruit 40 drug-abusing adolescents (20 male and 20 female, 14-17 years of age) who meet DSM-IV criteria for BPD, and their families. Participants will be recruited from the Juvenile Addictions Receiving Facility (JARF) at the University of Miami/Jackson Memorial Hospital and the Juvenile Assessment Center (JAC). The adolescents and their families will be randomly assigned to either the (1) I-BAFT condition, or (2) the Individual Drug Counseling (IDC) condition. Both treatment conditions are manualized and have adherence checklists available. Both I-BAFT and IDC will be implemented as seven-month interventions with two sessions per week. Assessments will be conducted at baseline, mid-treatment (4 months), post-treatment (8 months), and follow-up (12 months). Longitudinal data analysis (growth curve modeling) and Clinical Significance v/ill be used to test study hypotheses.

描述（由申请人提供）： 拟议的 I-B 阶段研究重点关注同时符合边缘性人格障碍 (BPD) 和药物滥用障碍标准的青少年。这些青少年表现出一种自我毁灭的行为模式（自杀未遂、自残、暴力反应），加剧了他们的药物滥用，并严重扰乱了治疗和家庭关系。这一系列症状及其严重程度需要专门的干预措施。之前 NIDA 资助的第一阶段研究导致了综合边缘青少年家庭治疗 (I-BAFT) 模型的发展，该模型整合了 1) Linehan 专门针对边缘成人的技能培训工作和 2) 基于结构家庭治疗的家庭治疗，该治疗被证明是有效的药物滥用青少年；3) 针对这一特定亚型的药物滥用者采取个人层面的干预措施。本申请拟开展一项“针对药物滥用障碍的行为和心理社会疗法的 I-B 阶段研究”，在一项小型随机试验中测试新开发的 I-BAFT，并对其功效进行更实质性的测试，以获得药物滥用所需的必要指标。第二阶段试验。除了关注药物和边缘性人格障碍的结果外，该研究还将获得对假设的中介因素（例如家庭功能和情绪调节）影响的初步指标。我们将招募 40 名符合 DSM-IV BPD 标准的吸毒青少年（20 名男性和 20 名女性，14-17 岁）及其家人。参与者将从迈阿密大学/杰克逊纪念医院的青少年成瘾接收设施 (JARF) 和青少年评估中心 (JAC) 招募。青少年及其家人将被随机分配到 (1) I-BAFT 条件，或 (2) 个人药物咨询 (IDC) 条件。两种治疗条件都是手动的，并且有可用的依从性检查表。 I-BAFT 和 IDC 都将实施为期七个月的干预措施，每周两次。评估将在基线、治疗中期（4 个月）、治疗后（8 个月）和随访（12 个月）时进行。纵向数据分析（生长曲线建模）和临床意义可用于检验研究假设。