Culturally Informed Family Based Treatment of Adolescents: A Randomized Trial

基于文化的青少年家庭治疗：一项随机试验

• 批准号: 8447115
• 负责人: DANIEL A. SANTISTEBAN
• 金额: $ 55.96万
• 依托单位: UNIVERSITY OF MIAMI CORAL GABLES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8447115
• 关键词: Acculturation; Address; Adolescent; Age; Area; Behavior; Behavior monitoring; Belief; Characteristics; Child; Clinical Treatment; Cluster Analysis; Communication; Conflict (Psychology); Couples; Decision Making; Development; Discrimination; Disease; Divorce; Dose; Drug abuse; Drug usage; Drug user; Education; Educational Intervention; Educational process of instructing; Effectiveness; Ensure; Family; Family Characteristics; Family Practice; Family Process; Family psychotherapy; Future; Goals; Hispanics; Home environment; Immigration; Individual; Intervention; Investigation; Legal; Lifestyle-related condition; Mainstreaming; Manuals; Manuscripts; Mediating; Mediator of activation protein; Minority; Modeling; Motivation; NIH Program Announcements; Outcome; Parenting behavior; Parents; Pharmaceutical Preparations; Problem behavior; Process; Publications; Randomized Clinical Trials; Recording of previous events; Relapse; Research; Risk Behaviors; Role; Single-Parent Family; Staging; Stress; Testing; Therapeutic; Treatment Efficacy; Treatment outcome; Woman; Work; Youth; adolescent drug abuse; adolescent substance use; base; clinically significant; contextual factors; dosage; effective therapy; flexibility; high risk sexual behavior; improved; innovation; interest; interpersonal conflict; meetings; middle school; motivational enhancement therapy; named group; public health relevance; randomized trial; reduced substance use; response; severe behavior problem; skills; stressor; therapy design; therapy development; treatment effect

DESCRIPTION (provided by applicant): This application proposes to conduct a Stage II randomized trial to test Culturally Informed & Flexible Family-Based Treatment for Adolescents (CIFFTA) a treatment developed as part of a Stage I treatment development effort and showing very promising preliminary findings. Drug use rate are highest among Hispanic middle school youth and to date there are few if any treatments that have been proven effective with substance abusing Hispanic adolescents. Further treatment for Hispanic youth and families is complicated by the fact that these families often differ from mainstream drug users in values, beliefs and behaviors that can directly impact engagement, retention, and efficacy/effectiveness of drug treatment. Our efforts to develop and fully test a more powerful treatment that can address these issues began with a Stage 1 study that: 1) led to the development of a flexible manual that allows treatment tailoring to the unique family characteristics, 2) showed highly promising feasibility and acceptability indicators (Santisteban and Mena, in press) and 3) showed highly promising preliminary outcomes on both drug use and family-level hypothesized mediators (Santisteban et al., unpublished manuscript). This application proposes a Stage II randomized trial with 220 Hispanic youngsters' ages 14-17 meeting criteria for drug abuse and their families. The study will test the treatment's efficacy compared to a control condition, in impacting drug use, risky sexual behavior, and hypothesized mechanisms (family functioning and therapeutic alliance) of change, in a larger and more rigorous trial. The study also includes a test of the dose-response relationship and exploration of moderators of treatment outcome. This application responds to a Program Announcement (PA-07-111) that outlines as areas of interest "...women, minorities, families, couples, specific cultural groups, adolescents..." The Stage II trial focuses on a treatment designed to boost the treatment effects by building in a flexible tailoring process to better address the specific needs of: 1) adolescents, 2) minorities and a special cultural group - Hispanics, via a treatment that works with 3) couples and families.

描述（由申请人提供）：本申请提议进行II期随机试验，以测试对青少年的文化知情和灵活的基于家庭的治疗（CIFFTA），作为I期治疗开发工作的一部分开发的治疗方法，并显示出非常有前途的初步发现。在西班牙裔中学青年中，药物使用率最高，迄今为止，没有任何被证明有效的滥用西班牙裔青少年的治疗方法。这些家庭在价值，信念和行为方面通常与主流药物使用者有所不同，从而使西班牙裔青年和家庭的进一步治疗变得复杂。我们努力开发和全面测试更有力的治疗方法，可以解决这些问题，始于一项第一阶段研究：1）开发了一本灵活的手册，该手册允许对独特的家庭特征量身定制治疗，2）表现出非常有希望的可行性以及可接受性指标（Santisteban和Mena，印刷中）和3）在毒品使用和家庭水平的假设介体方面都表现出高度有希望的初步结果（Santisteban等人，未发表的手稿）。该申请提出了一项II期随机试验，其中有220名西班牙裔青少年14-17岁的滥用药物标准及其家人。在一项更大，更严格的试验中，该研究将在影响药物使用，风险的性行为（家庭功能和治疗联盟）方面测试治疗条件的功效，并在影响毒品的使用，风险的性行为和假设的机制（家庭功能和治疗联盟）方面。该研究还包括对剂量反应关系的测试以及对治疗结果的主持人的探索。该申请响应了一个计划公告（PA-07-111），该公告概述了感兴趣的领域：“ ...妇女，少数民族，家庭，夫妻，特定的文化团体，青少年……”第二阶段试验侧重于设计的治疗通过在灵活的剪裁过程中构建以更好地满足以下特定需求：1）青少年，2）少数民族和一个特殊的文化群体 - 西班牙裔，通过与3）夫妇和家庭一起使用的治疗方法来更好地解决治疗效果。