QUANTITATIVE PERFORMANCE ASSESSMENT OF THE AIDS DEMENTIA COMPLEX

艾滋病痴呆症的定量表现评估

• 批准号: 6112303
• 负责人: JOHN J SIDTIS
• 金额: --
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-01 至 1999-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6112303
• 关键词: AIDS dementia complex; AIDS therapy; HIV infections; attention; audiometry; auditory stimulus; behavioral /social science research tag; biomedical automation; brain electrical activity; cognition; computer program /software; disease /disorder classification; electroencephalography; evoked potentials; human subject; human therapy evaluation; method development; neuropsychological tests; neuropsychology; performance; psychomotor reaction time; stimulus /response; visual stimulus

This new project seeks to extend the work on neuropsychological assessment accomplished in the Program's initial period of funding. Its objective is to extend the current method of quantitative performance evaluation of ADC, focussing on more sensitive measures that might prove valuable in multidisciplinary studies directed at the underlying pathophysiological mechanism of ADC. Starting with a well-standardized procedure, this project will establish the utility of a Continuous Performance Task (CPT), using a reaction time measure of sustained attention to characterize ADC. The utility of CPT as a sensitive, early measure of treatment effects in studies of anti-retroviral therapy and of therapies directed at potential neuropathophysiological mechanisms of ADC will also be studied. As a correlate of the CPT measure, its corresponding event related potential (ERP) will also be studied with respect to ADC. Both the CPT and event related potential measures will be studied during FDG/PET scanning in collaboration with Project 4. The objective of these studies is not to replace the previously established methods of the neuropsychological assessment of ADC, but to develop more sensitive measures of impairment in this syndrome that can play a significant role in studying treatment effects and potential pathophysiological mechanisms. In the context of this Program, these studies will be integrated with the studies of regional cerebral metabolism, quantitative MRI, and EEG power spectra, and will play an important role in correlative studies using surrogate markers of direct and indirect effects of HIV-1 infection of the CNS.

这个新项目旨在扩展有关神经心理学的工作 评估在该计划的初始资金阶段完成。 它是 目的是扩展当前定量性能的方法 评估ADC，重点放在可能证明的更敏感的措施上 在针对基础的多学科研究中有价值 ADC的病理生理机制。 从标准的 程序，该项目将确定连续的实用性 绩效任务（CPT），使用持续的反应时间度量 注意表征ADC。 CPT作为敏感的早期的实用性 治疗效应在抗逆转录病毒疗法的研究中 针对潜在神经病理生理机制的疗法 也将研究ADC。 作为CPT度量的相关性，它 还将研究相关事件相关电位（ERP） 尊重ADC。 CPT和与事件相关的潜在措施都将 在FDG/PET扫描期间与项目4合作进行研究。 这些研究的目的不是取代先前建立的 ADC神经心理学评估的方法，但要发展更多 该综合征的敏感措施可以发挥作用 在研究治疗效果和潜力中的重要作用 病理生理机制。 在此程序的背景下，这些 研究将与区域大脑的研究集成 代谢，定量MRI和EEG功率谱，将播放 使用直接的替代标记物在相关研究中的重要作用 和中枢神经系统的HIV-1感染的间接作用。