IN VIVO ULTRASONIC MICROPROBE FOR TUMOR DIAGNOSIS

用于肿瘤诊断的体内超声显微探针

• 批准号: 2710688
• 负责人: William D. O'Brien
• 金额: $ 12.59万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2710688
• 关键词: biomedical equipment development; cell component structure /function; clinical biomedical equipment; diagnosis design /evaluation; histopathology; image processing; imaging /visualization /scanning; interdisciplinary collaboration; laboratory mouse; laboratory rat; neoplasm /cancer diagnosis; neoplastic cell; noninvasive diagnosis

The objective of this two-year initiative is to develop the basis for a fundamentally new technology for an in situ clinical diagnosis of solid tumors with the expectation of rapid and accurate detection and diagnosis of cancer. The research approach is interdisciplinary (acoustic and electrical engineers, image and signal processor, material scientists, and board-certified veterinary pathologist). Given the important in patient health-care management of obtaining a highly accurate and timely diagnosis of a tumor and the difficulties, processing time, and risks associated with surgical and aspirational biopsies, a technique which would permit the evaluation of tumors in situ would be enormously beneficial medically and cost effective. The specific aims of this two-year initiative are: (1) to identify ultrasonic image features of tissues and cells that differentiate cytoarchitectural features of normal tissues from selected neoplastic tissues using well-established non-invasive pulse-echo data acquisition schemes and high-definition image formation techniques applicable for the invasive in vivo ultrasonic microprobe geometry, (3) to construct and evaluate invasive in vivo ultrasonic microprobes using two separate construction approaches, and (4) to identify ultrasonic image features of tissues and cells that differentiate cytoarchitectural features of normal tissues from selected neoplastic tissues using the invasive in vivo ultrasonic microprobes. Light microscopic histopathologic evaluation of the identical tissues by a board-certified veterinary pathologist will be used as the gold standard. Three categories of ultrasonic data acquisition are proposed, viz., non- invasive using commercial transducers; invasive microprobe using existing, commercially available materials; and invasive microprobe using newly developed materials. Conventional B-mode and C-mode imaging techniques will be investigated. In addition, it is proposed to adapt signal processing techniques from synthetic aperture radar (SAR) imaging techniques. Also, image formation and enhancement methods will be tested and verified on stimulate data based on a full-fledged statistical model of the ultrasound imaging processing, adopting an enhanced version of the standard fully-developed-speckle model.

这项为期两年的举措的目标是为 用于固体原位临床诊断的全新技术 期望快速、准确地检测和诊断肿瘤 癌症。研究方法是跨学科的（声学和 电气工程师、图像和信号处理器、材料科学家，以及 委员会认证的兽医病理学家）。鉴于对患者的重要性 获得高度准确和及时诊断的医疗保健管理 肿瘤的相关困难、处理时间和风险 通过手术和抽吸活检，这种技术将允许 原位评估肿瘤在医学上将非常有益 且具有成本效益。 这项为期两年的举措的具体目标是： (1) 确定 区分组织和细胞的超声图像特征 选定肿瘤的正常组织的细胞结构特征 使用成熟的非侵入性脉冲回波数据采集的组织 适用于的方案和高清图像形成技术 侵入性体内超声微探针几何结构，（3）构建和 使用两个独立的评估侵入式体内超声微探针 构造方法，以及（4）识别超声图像特征 区分正常细胞结构特征的组织和细胞 使用侵入性体内技术从选定的肿瘤组织中提取组织 超声波微探针。光镜组织病理学评估 经委员会认证的兽医病理学家将使用相同的组织 用作金标准。 提出了三类超声波数据采集，即非 使用商业换能器进行侵入式；使用现有的侵入式微探针， 市售材料；和侵入式微探针使用新 开发的材料。传统的 B 模式和 C 模式成像技术 将被调查。此外，建议调整信号 合成孔径雷达 (SAR) 成像的处理技术 技术。此外，还将测试图像形成和增强方法 并根据成熟的统计模型对刺激数据进行验证 超声成像处理，采用增强版本 标准的完全发展的散斑模型。