IN VIVO ULTRASONIC MICROPROBE FOR TUMOR DIAGNOSIS

用于肿瘤诊断的体内超声显微探针

• 批准号: 2710688
• 负责人: William D. O'Brien
• 金额: $ 12.59万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2710688
• 关键词: biomedical equipment development; cell component structure /function; clinical biomedical equipment; diagnosis design /evaluation; histopathology; image processing; imaging /visualization /scanning; interdisciplinary collaboration; laboratory mouse; laboratory rat; neoplasm /cancer diagnosis; neoplastic cell; noninvasive diagnosis

The objective of this two-year initiative is to develop the basis for a fundamentally new technology for an in situ clinical diagnosis of solid tumors with the expectation of rapid and accurate detection and diagnosis of cancer. The research approach is interdisciplinary (acoustic and electrical engineers, image and signal processor, material scientists, and board-certified veterinary pathologist). Given the important in patient health-care management of obtaining a highly accurate and timely diagnosis of a tumor and the difficulties, processing time, and risks associated with surgical and aspirational biopsies, a technique which would permit the evaluation of tumors in situ would be enormously beneficial medically and cost effective. The specific aims of this two-year initiative are: (1) to identify ultrasonic image features of tissues and cells that differentiate cytoarchitectural features of normal tissues from selected neoplastic tissues using well-established non-invasive pulse-echo data acquisition schemes and high-definition image formation techniques applicable for the invasive in vivo ultrasonic microprobe geometry, (3) to construct and evaluate invasive in vivo ultrasonic microprobes using two separate construction approaches, and (4) to identify ultrasonic image features of tissues and cells that differentiate cytoarchitectural features of normal tissues from selected neoplastic tissues using the invasive in vivo ultrasonic microprobes. Light microscopic histopathologic evaluation of the identical tissues by a board-certified veterinary pathologist will be used as the gold standard. Three categories of ultrasonic data acquisition are proposed, viz., non- invasive using commercial transducers; invasive microprobe using existing, commercially available materials; and invasive microprobe using newly developed materials. Conventional B-mode and C-mode imaging techniques will be investigated. In addition, it is proposed to adapt signal processing techniques from synthetic aperture radar (SAR) imaging techniques. Also, image formation and enhancement methods will be tested and verified on stimulate data based on a full-fledged statistical model of the ultrasound imaging processing, adopting an enhanced version of the standard fully-developed-speckle model.

这项为期两年倡议的目的是为 从根本上讲，新技术，用于现场临床诊断的固体诊断 肿瘤预期快速，准确的检测和诊断 癌症。研究方法是跨学科的（声学和 电气工程师，图像和信号处理器，材料科学家以及 董事会认证的兽医病理学家）。鉴于患者很重要 获得高度准确及时诊断的医疗保健管理 肿瘤和困难，处理时间和风险 使用手术和理想的活检，该技术将允许 对原位肿瘤的评估在医学上会非常有益 并具有成本效益。 这项两年倡议的具体目的是：（1）确定 分化的组织和细胞的超声图像特征 来自选定肿瘤的正常组织的细胞结构特征 使用完善的非侵入性脉搏回声数据采集的组织 方案和高清图像形成技术适用于 侵入性体内超声波微探针几何形状（3）构造和 使用两个独立 建筑方法和（4）确定超声图像特征 分化正常细胞结构特征的组织和细胞 利用体内侵入性的肿瘤组织的组织 超声波菌。轻度微观组织病理学评估 通过董事会认证的兽医病理学家相同的组织将是 用作黄金标准。 提出了三类超声数据采集，即非 - 使用商业传感器的侵入性；使用现有的侵入性微探针 市售材料；并使用新的侵入性微探针 开发材料。常规的B模式和C模式成像技术 将被调查。另外，提议适应信号 合成孔径雷达（SAR）成像的处理技术 技术。另外，将测试图像形成和增强方法 并根据成熟的统计模型对刺激数据进行验证 超声成像处理，采用增强版本 标准完全开发的销售模型。