High-Resolution In Vivo Ultrasound Imaging Using VisualSonics VEVO 2100 System

使用 VisualSonics VEVO 2100 系统进行高分辨率体内超声成像

• 批准号: 7793999
• 负责人: William D. O'Brien
• 金额: $ 47.95万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7793999
• 关键词: Animal Model; Animals; Basic Science; Clinical; Communities; Felis catus; Frequencies; Funding; Funding Applicant; Funding Mechanisms; Grant; Illinois; Longitudinal Studies; Minor; Mus; Oryctolagus cuniculus; Rana; Rattus; Research; Research Personnel; Resolution; Seminal; System; Ultrasonography; United States National Institutes of Health; Universities; base; human disease; in vivo; public health relevance; quantitative ultrasound

DESCRIPTION (provided by applicant): Funds are requested via the S10 NIH funding mechanism to purchase a VisualSonics Vevo 2100 high-resolution small-animal ultrasound imaging system to be shared by 10 major projects (representing 6 investigators who have 12 NIH-funded grants) and 6 minor projects. Each of the 16 projects will yield value-added benefits from the use of the Vevo 2100. Such a shared capability does not exist at the University of Illinois although many of the seminal ultrasound imaging discoveries can be traced to the more than 60 years of basic science ultrasound research at the University of Illinois. However, as the University investigators transition their research closer to direct clinical activities, high- frequency ultrasound imaging (qualitative and quantitative) of small animals under efficient high- throughput and longitudinal study conditions require the type of system being requested. Our proposal outlines the (1) scientific need; (2) technical support, administration, oversight; (3) representative investigator research applications; (4) institutional commitment; and (5) academic community benefit of our proposed VisualSonics Vevo 2100 system. The Vevo 2100 will be managed by a team with established ultrasound expertise and animal-based studies (included herein: frog, mouse, rat, rabbit, cat) with substantial institutional support. General Relevance: Our proposed VisualSonics Vevo 2100 system provides users with high-resolution qualitative and quantitative ultrasound imaging capabilities in order to better develop, characterize, and treat human diseases using small animal models. PUBLIC HEALTH RELEVANCE: Funds are requested via the S10 NIH funding mechanism to purchase a VisualSonics Vevo 2100 high-resolution small-animal ultrasound imaging system to be shared by 10 major projects (representing 6 investigators who have 12 NIH-funded grants) and 6 minor projects. Such a shared capability does not exist at the University of Illinois although many of the seminal ultrasound imaging discoveries can be traced to the more than 60 years of basic science ultrasound research at the University of Illinois. Our proposed Vevo 2100 system provides users with high-resolution qualitative and quantitative ultrasound imaging capabilities in order to better develop, characterize, and treat human diseases using small animal models.

描述（由申请人提供）：通过 S10 NIH 资助机制申请资金购买 VisualSonics Vevo 2100 高分辨率小动物超声成像系统，由 10 个主要项目共享（代表 6 位研究人员，他们拥有 12 项 NIH 资助的资助）和6个小项目。这 16 个项目中的每一个都将通过使用 Vevo 2100 产生增值效益。尽管许多开创性的超声成像发现可以追溯到 60 多年的基础研究，但伊利诺伊大学并不存在这种共享能力。伊利诺伊大学的科学超声研究。然而，随着大学研究人员将他们的研究转向更直接的临床活动，在高效的高通量和纵向研究条件下对小动物进行高频超声成像（定性和定量）需要所要求的系统类型。我们的提案概述了 (1) 科学需求； (2) 技术支持、管理、监督； （三）代表性研究者的研究申请； （四）制度承诺； (5) 我们提出的 VisualSonics Vevo 2100 系统对学术界的好处。 Vevo 2100 将由具有成熟的超声专业知识和基于动物的研究（包括青蛙、小鼠、大鼠、兔子、猫）的团队管理，并提供大量机构支持。一般相关性：我们提出的 VisualSonics Vevo 2100 系统为用户提供高分辨率定性和定量超声成像功能，以便使用小动物模型更好地开发、表征和治疗人类疾病。 公共健康相关性：通过 S10 NIH 资助机制申请资金购买 VisualSonics Vevo 2100 高分辨率小动物超声成像系统，由 10 个主要项目（代表拥有 12 项 NIH 资助的 6 名研究人员）和 6 个次要项目共享项目。尽管许多开创性的超声成像发现可以追溯到伊利诺伊大学 60 多年的基础科学超声研究，但伊利诺伊大学并不存在这种共享能力。我们提出的 Vevo 2100 系统为用户提供高分辨率定性和定量超声成像功能，以便使用小动物模型更好地开发、表征和治疗人类疾病。