Quantitative Ultrasonic Imaging of the Breast

乳房定量超声成像

• 批准号: 8097415
• 负责人: William D. O'Brien
• 金额: $ 85.46万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8097415
• 关键词: Acoustics; Algorithms; Animal Model; Animals; Biological; Biopsy; Breast; Caliber; Classification; Clinical; Data; Databases; Development; Diagnosis; Diagnostic; Diagnostic Imaging; Disease; Early Diagnosis; Effectiveness; Engineering; Foundations; Goals; Illinois; Image; Imaging Techniques; In Situ; In Vitro; Internet; Laboratories; Lead; Lesion; Mammary Neoplasms; Maps; Measurement; Methods; Modality; Modeling; Monitor; Normal tissue morphology; Pathologic; Pathologist; Performance; Phase II Clinical Trials; Process; Property; Relative (related person); Research; Research Personnel; Resolution; Scanning; Shapes; Signal Transduction; Solid; Solid Neoplasm; Source; Staging; Structure; Techniques; Testing; Time; Tissues; Ultrasonics; Ultrasonography; Universities; Variant; Wisconsin; Work; acoustic imaging; attenuation; base; breast lesion; cancer site; density; electric impedance; expectation; feeding; human subject; improved; in vivo; in vivo Model; novel; novel strategies; outreach; quantitative ultrasound; radiofrequency; radiologist; research clinical testing; research study; response; simulation; tool; tumor; tumor growth

DESCRIPTION (provided by applicant): The long-term goal of the proposed partnership is to develop, unify, refine and implement a new approach to quantitative ultrasound (QUS) imaging of biological tissues and mammary tumors by the quantification of tissue microstructure. In lay terms, if the research is successful, many breast abnormalities and lesions can be diagnosed without the need for a biopsy. The overall hypothesis of our partnership is that a set of QUS parameters can significantly improve breast lesion differentiation/classification. The primary QUS parameters to be exploited include attenuation, scatterer size, scatterer number density, and acoustic concentration (scatterer number density times their impedance change). Our goal in the first 5 years of this project is to lay the foundation for a new (possibly revolutionary but definitely evolutionary) diagnostic imaging capability through development, testing, and verification with simulations, phantoms, and in vitro and in vivo animal model experiments, as well as preliminary human subjecting testing. In the second 5 years we will extend the analysis beyond common breast lesions, begin Phase II clinical trials and work towards the creation of automated tools to assist in the diagnosis of breast abnormalities. The partnership is between engineers, acoustic physicists, statisticians and veterinary pathologists at UIUC and physicists, engineers, pathologists and radiologists at UW. The PI is William D. O'Brien, Jr. (UIUC), and functioning as the co-Pi is Timothy J. Hall (UW). Use of QUS imaging is medically significant because it offers a potentially real-time and noninvasive means of differentiation/classification tumor types and tracking their response to therapy. To this end, 5 specific aims are proposed, viz., 1) unify QUS algorithms with simulations, phantoms and animal tumor models in vivo, 2) associate acoustic microstructural measurements with anatomical scattering sources, 3) monitor the changes in QUS parameters with tumor growth in in vivo animal models, 4) compare tumors in human subjects with those in animal models, and 5) develop a major outreach activity.

描述（由申请人提供）：拟议合作伙伴关系的长期目标是开发、统一、完善和实施一种通过组织微观结构的量化对生物组织和乳腺肿瘤进行定量超声（QUS）成像的新方法。通俗地说，如果研究成功，许多乳房异常和病变就可以诊断出来，而无需进行活检。我们合作的总体假设是一组 QUS 参数可以显着改善乳腺病变的分化/分类。要利用的主要 QUS 参数包括衰减、散射体尺寸、散射体数量密度和声集中度（散射体数量密度乘以它们的阻抗变化）。我们在该项目前 5 年的目标是通过模拟、体模以及体外和体内动物模型实验的开发、测试和验证，为新的（可能是革命性的，但绝对是进化的）诊断成像能力奠定基础。以及初步的人体测试。在接下来的 5 年里，我们将把分析扩展到常见的乳腺病变之外，开始 II 期临床试验，并致力于创建自动化工具来协助诊断乳腺异常。该合作伙伴关系是伊利诺伊大学香槟分校的工程师、声学物理学家、统计学家和兽医病理学家与威斯康星大学的物理学家、工程师、病理学家和放射学家之间的合作。 PI 是 William D. O'Brien, Jr. (UIUC)，联合 Pi 是 Timothy J. Hall (UW)。 QUS 成像的使用具有重要的医学意义，因为它提供了一种潜在的实时和非侵入性的肿瘤类型分化/分类方法，并跟踪其对治疗的反应。为此，提出了 5 个具体目标，即 1）将 QUS 算法与体内模拟、体模和动物肿瘤模型统一起来，2）将声学微观结构测量与解剖散射源相关联，3）监测 QUS 参数与肿瘤的变化体内动物模型中的生长，4) 将人类受试者的肿瘤与动物模型中的肿瘤进行比较，以及 5) 开展主要的外展活动。

项目成果

Ultrasound attenuation measurements using a reference phantom with sound speed mismatch.

• DOI: 10.1177/016173461103300404
• 发表时间: 2011-10
• 期刊: Ultrasonic imaging
• 影响因子: 2.3
• 作者: Nam K;Rosado-Mendez IM;Rubert NC;Madsen EL;Zagzebski JA;Hall TJ
• 通讯作者: Hall TJ

Task-oriented comparison of power spectral density estimation methods for quantifying acoustic attenuation in diagnostic ultrasound using a reference phantom method.

• DOI: 10.1177/0161734613495524
• 发表时间: 2013-07
• 期刊: Ultrasonic imaging
• 影响因子: 2.3
• 作者: Rosado-Mendez IM;Nam K;Hall TJ;Zagzebski JA
• 通讯作者: Zagzebski JA

Estimating the total ultrasound attenuation along the propagation path by applying multiple filters to backscattered echoes from a single spherically focused source.

• DOI: 10.1109/tuffc.2010.1494
• 发表时间: 2010-04
• 期刊: IEEE transactions on ultrasonics, ferroelectrics, and frequency control
• 作者: Bigelow T

Quantitative ultrasound from single cells to biophantoms to tumors.

从单细胞到生物体模再到肿瘤的定量超声。

• DOI: 10.1109/embc.2012.6346131
• 发表时间: 2012
• 期刊: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
• 作者: O'BrienJr,WilliamD;Han,Aiguo;Auger,Thomas
• 通讯作者: Auger,Thomas

Optimization of the algorithms for estimating the ultrasonic attenuation along the propagation path.

优化估计沿传播路径的超声波衰减的算法。

• DOI: 10.1016/j.ultras.2012.01.011
• 发表时间: 2012
• 期刊: Ultrasonics
• 影响因子: 4.2
• 作者: Labyed,Yassin;Bigelow,TimothyA
• 通讯作者: Bigelow,TimothyA