PERUVIAN MEDICINAL PLANT SOURCES OF NEW PHARMACEUTICALS

新药品的秘鲁药用植物来源

• 批准号: 2635844
• 负责人: WALTER H LEWIS
• 金额: $ 20.6万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-01 至 1999-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2635844
• 关键词: Peru; alternative medicine; cooperative study; drug screening /evaluation; medicinal plants; tropical medicine

DESCRIPTION (adapted from investigator's abstract): The long-term objectives of the Ethnomedicinal Plants Associate Program are to collect plants which have been used medicinally by people in Peru and elsewhere in South America for generations to treat a broad range of illnesses; these plants are thus already targeted or prescreened for testing using current biomedical techniques. Primary screens will be conducted to test for activity against a number of infective agents, including respiratory viruses, herpes viruses, pathogenic yeasts, and tuberculosis. When crude extracts prove positive in primary and also secondary screens, biodirected assays will allow active fractions to be identified to biodynamic compound. Isolation and characterization of these principles will provide phytochemicals which could be developed into new pharmaceuticals of substantial benefit to human health globally. In collaboration with the Ecology and Resource Management program an important contribution will be to identify and help grow those medicinal plants needed in research development and for commercial use. Successful cultivation should lead to a greater value being placed on the forests and surrounding areas, and if this worth proves sufficient, the probability that deforestation will be reduced and biodiversity retained is enhanced.

描述（根据研究者的摘要进行了改编）： 民族医学植物助理计划的长期目标 是收集秘鲁人在药用使用的植物 以及南美其他地方的几代人，以对待广泛的 疾病；因此，这些植物已经针对或预先筛选 使用当前的生物医学技术进行测试。主屏幕将是 进行测试针对许多感染剂的活性， 包括呼吸道病毒，疱疹病毒，致病酵母和 结核。 当原油在初级及其中证明是阳性的 次级屏幕，生物形式的测定将使主动分数为 鉴定为生物动力化合物。 隔离和表征 这些原则将提供可以开发的植物化学物质 进入对人类健康的重大利益的新药物 全球。 与生态和资源管理合作 计划的重要贡献是识别和帮助成长 研究开发和商业上需要的那些药用植物 使用。 成功的种植应导致更大的价值 在森林和周边地区，如果这一点证明了这一点 足够，森林砍伐的概率将减少和 保留的生物多样性得到了增强。