ETHNOMEDICINAL PLANTS

民族药用植物

• 批准号: 6123777
• 负责人: WALTER H LEWIS
• 金额: $ 5.23万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 2000-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6123777
• 关键词: Peru; antiinfective agents; antineoplastics; antiprotozoal agents; drug screening /evaluation; ethnic group; gastrointestinal agents; human subject; human therapy evaluation; leishmaniasis; medicinal plants; tropical medicine; Peru; antiinfective agents; antineoplastics; antiprotozoal agents; drug screening /evaluation; ethnic group; gastrointestinal agents; human subject; human therapy evaluation; leishmaniasis; medicinal plants; tropical medicine

Long-term objectives are to provide the materials whereby biodynamic compound will be discovered and developed as pharmaceuticals for improving human well-being in specific health areas, while at the same time providing for sustained economic growth and the conservation of biodiversity in northern Peru. Fundamental to these aims is the collection of plants which have been used medicinally by peoples in Peru and elsewhere in South America for generations to treat a broad range of illnesses; these plants are thus already targeted or prescreened for testing using current biomedical techniques. Primary screens will be conducted to test for activity against a number of infective agents, including respiratory viruses, herpes viruses, pathogenic yeasts, and tuberculosis. When crude extracts prove positive in primary and also secondary screens, biodirected assays will allow active fractions to be identified to biodynamic compound. Isolation and characterization of these principles will provide phytochemicals which could be developed into new pharmaceuticals of substantial benefit to human health globally. Furthermore, an important contribution will be to identify and help grow those medicinal plants needed in research development and for commercial use. Successful cultivation should lead to a greater value being placed on the forests and surroundings areas, and if this worth proves sufficient, the probability that deforestation will be reduced and biodiversity retained is enhanced.

长期目标是提供生物动力的材料 化合物将被发现并开发为药物 改善特定卫生领域的人类福祉，而同时 为持续经济增长和保护的时间提供 秘鲁北部的生物多样性。这些目标是 秘鲁人民用药用使用的植物收集 以及南美其他地方的几代人，以对待广泛的 疾病；因此，这些植物已经针对或预先筛选 使用当前的生物医学技术进行测试。主屏幕将是 进行测试针对许多感染剂的活性， 包括呼吸道病毒，疱疹病毒，致病酵母和 结核。当原油在初级及其中证明是阳性的 次级屏幕，生物形式的测定将使主动分数为 鉴定为生物动力化合物。隔离和表征 这些原则将提供可以开发的植物化学物质 进入全球人类健康的新药物。 此外，重要的贡献是识别和帮助成长 研究开发和商业上需要的那些药用植物 使用。成功的种植应导致更大的价值 在森林和周围地区，如果这一点证明了这一点 足够，森林砍伐的概率将减少和 保留的生物多样性得到了增强。