Phosphoinositide regulation of lysosome reformation during autophagy

自噬过程中磷酸肌醇对溶酶体重组的调节

• 批准号: DP190102499
• 负责人: Prof Christina Mitchell
• 金额: $ 33.36万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-03-18 至 2022-03-17
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190102499
• 关键词: Phosphoinositide; regulation; lysosome; reformation; during

This project aims to investigate a new critical step in the autophagy pathway, autophagic lysosome reformation, a fundamental, evolutionarily conserved mechanism for cellular homeostasis. By combining gene function studies with advanced cellular imaging techniques, this project will investigate the dynamic membrane changes that drive this lysosome recycling pathway and how it is regulated by a hierarchical succession of specific enzymes. The expected outcome will be to re-define the archetypical autophagy pathway and characterise novel mechanisms by which it is controlled. This project will reveal new fundamental biological processes, and act as a framework for developing new imaging modalities and tools for studying autophagy.

该项目旨在研究自噬途径，自噬溶酶体改革的新关键步骤，这是一种基本的，进化保守的细胞稳态机制。通过将基因功能研究与先进的细胞成像技术相结合，该项目将研究驱动该溶酶体回收途径的动态膜变化，以及如何通过特定酶的层次继承来调节它。预期的结果将是重新定义原型自噬途径，并表征其控制的新机制。该项目将揭示新的基本生物学过程，并充当开发研究自噬的新成像方式和工具的框架。