The role of PtdIns(4,5)P2 in cellular responses in Saccharomyces cerevisiae.

PtdIns(4,5)P2 在酿酒酵母细胞反应中的作用。

• 批准号: DP0663923
• 负责人: Prof Christina Mitchell
• 金额: $ 17.98万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-03 至 2008-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0663923
• 关键词: role; PtdIns; P2; cellular; responses

This grant application falls under the criteria of frontier technologies in genomics/phenomics and complex systems. We are characterizing a highly conserved network of signaling molecules regulated by complex large families of enzymes that regulate the bending of membranes, and cellular events including cell division in plants, yeast and mammalian cells. We have developed cutting edge novel technologies to localize signaling on specific intracellular membranes and visualise the role cellular lipids play in forming tubules in cells. This project will result in the presentation of Australian research at international forums and support the training of PhD students.

该赠款应用属于基因组学/现象学和复杂系统边界技术的标准。我们正在表征由调节膜弯曲的复杂大型酶调节的高度保守信号分子网络，以及包括植物，酵母和哺乳动物细胞中细胞分裂的细胞分裂。我们已经开发了尖端的新型技术，可以将信号定位在特定的细胞内膜上，并可视化细胞脂质在形成细胞中的小管中的作用。该项目将导致在国际论坛上介绍澳大利亚研究，并支持博士生的培训。