The role of phosphoinositides in endosomal maturation dynamics.

磷酸肌醇在内体成熟动力学中的作用。

• 批准号: DP220103810
• 负责人: Prof Christina Mitchell
• 金额: $ 41.77万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220103810
• 关键词: role; phosphoinositides; endosomal; maturation; dynamics.

This project aims to investigate the regulation of an intracellular compartment within a cell called endosomes, which plays critical roles in cellular homeostasis, signalling and pathogen entry. New knowledge is expected to be generated in understanding endosome maturation and the signalling events that drive this process using a unique, multidisciplinary approach combining state of the art imaging techniques and high throughput protein analysis. The anticipated outcomes will be to define the molecular steps that govern the membrane-bound machinery on endosomes that directs endosomal maturation. This should provide significant benefits in delineating a process that is linked to almost all aspects of cell life.

该项目旨在调查称为内体的细胞内的细胞内室的调节，该细胞在细胞内稳态，信号传导和病原体进入中起关键作用。预计将在理解内体成熟和使用独特的多学科方法来驱动此过程的信号事件中产生新知识，从而结合了艺术成像技术和高吞吐量蛋白质分析。预期的结果将是定义指导内体成熟的内体上膜结合机械的分子步骤。这应该在描述与细胞寿命几乎所有方面相关的过程中提供重大好处。